The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney disease (CKD) and six hyperthyroid (HT) cats to assess potential differences in glomerular filtration rate (GFR) measurement over a wide range of GFR values. The PECCT, PexICT and PenICT were performed in a combined protocol. There was a significant difference between PexICT and PenICT and PECCT in healthy cats. Differences between clearance techniques are suggested to be correlated to range in GFRs and should be taken into account when GFR is measured.
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van Hoek I.,Vandermeulen E.,Duchateau L., et al.Comparison and reproducibility of plasma clearance of exogenous creatinine, exo-iohexol, endo-iohexol, and 51Cr-EDTA in young adult and aged healthy cats.J Vet Intern Med. 2007;21:950-958
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Brown S.A.,Haberman C.,Finco D.R..Use of plasma clearance of inulin for estimating glomerular filtration rate in cats.Am J Vet Res. 1996;57:1702-1705
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Miyamoto K..Evaluation of plasma clearance of inulin in clinically normal and partially nephrectomized cats.Am J Vet Res. 2001;62:1332-1335
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Miyamoto K..Use of plasma clearance of iohexol for estimating glomerular filtration rate in cats.Am J Vet Res. 2001;62:572-575
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Ross L.A.,Finco D.R..Relationship of selected clinical renal function tests to glomerular filtration rate and renal blood flow in cats.Am J Vet Res. 1981;42:1704-1710
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McClellan J.M.,Goldstein R.E.,Erb H.N.,Dykes N.L.,Cowgill L.D..Effects of administration of fluids and diuretics on glomerular filtration rate, renal blood flow, and urine output in healthy awake cats.Am J Vet Res. 2006;67:715-722
