Association of Two Polymorphisms in the Peroxisome Proliferator-Acativated Receptor-γ Gene With Adenomyosis,Endometriosis,and Leiomyomata in Japanese Women

Abstract

Objective: The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor that plays an important role in many diseases. This study investigated whether two polymorphisms (Pro12Ala in exon B and C161T in exon 6) of the PPAR-γ2 gene are related to adenomyosis, endometriosis, or leiomyomata.

Methods: A total of 390 patients with adenomyosis, endometriosis, and/or leiomyomata were classified into four groups: 103 patients with adenomyosis (21 adenomyosis only and 82 adenomyosis with endometriosis and/or leiomyomata), 95 patients with endometriosis only, 100 patients with leiomyomata only, and 92 patients with endometriosis and leiomyomata.

Results: There was no association between distribution of genotype or allele frequencies for the PPAR-γ Pro12Ala polymorphism and the presence of adenomyosis, endometriosis, and/or leiomyomata. However, compared with results for controls, the PPAR-γ 161CC genotype and 161C allele frequencies were significantly increased in patients with adenomyosis (genotype: χ² = 9.185, corrected P value [Pc] = .0169; allele: χ² = 8.337, Pc = .0155) and in patient with endometriosis (genotype: χ² = 6.748, Pc = .0375; allele: χ² = 6.413, Pc = .0453).

Conclusion: The results suggest that the PPAR-γ 161CC genotype could be a genetic risk factor for adenomyosis and endometriosis, whereas the Pro12Ala polymorphism was not associated with these estrogen-dependent benign uterine diseases in a Japanese population.

Keywords

Adenomyosis endometriosis genetic risk factor leiomyomata PPAR-γ gene polymorphism

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