Association of HLA-DQA1 ∗ 03011-DQB1 ∗ 0301 haplotype with the development of respiratory scleroma

Abstract

Objective

Respiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA-DQ3. In this study, molecular association of HLA class II and RS was determined.

Study Design and Setting

Nine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.

Results

Statistical analysis demonstrated association between DQB1^*0301 and susceptibility to RS (P_c = 0.004). Haplo-type analysis showed an association of DQA1^*03011-DQB1^*0301 (P = 1.21E-19) and DRB1^*0407-DQA1^*03011-DQB1^*0301 (P = 0.0002).

Conclusions

Results established that DQA1^*03011-DQB1^*0301 haplotype is a strong risk factor for development of RS.

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