Abstract
Objectives
The objectives of this study are to investigate the frequencies of single nucleotide polymorphism (SNP) of COX-2 and IL-10 in control group and the head and neck squamous cell carcinoma (HNSCC) patient group in Korean population and to analyze the correlation of COX-2 (−1329A>G, + 1266C>T, +6365T>C) and IL-10(−1082A>G, +920T>G, +3917T>C) polymorphisms of HNSCC patient group in Korean population.
Methods
Study was performed for 290 Korean head and neck squamous cell carcinoma patients and 358 healthy controls. DNA extraction of peripheral whole blood was done and genotyping was done by single base extension(SBE) and Taq-Man assay. We analyze the frequencies of SNP of cox-2(−1329A>G, +1266C>T, +6365T>C) and IL-10(−1082A>G, +920T>G, +3917T⋉C) and the following results were obtained.
Results
There is no statistical difference between carcinoma patients and healthy controls about frequencies of SNP of cox-2(−1329A>G, +1266C>T, +6365T>C) and IL-10 (−1082A>G, +920T>G, +3917T>C) except haplotype3(-/-, ht3/-, ht3/ht3) of COX-2 (−1329A>G, +1266C>T, +6365T>C) (Odds ratio: 0.60, p value: 0.03) in Korean populations.
Conclusions
Based on these results, it is suggested that COX-2(−1329A>G, +1266C>T, +6365T>C), IL-10 (−1082A>G, +920T>G, +3917T>C) genetic polymorphisms might not be correlated with head and neck squamous cell carcinoma in Korean populations but haplotype3 (ht3) of COX-2 might be associated with HNSCC.
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