Scientific Programme

Abstract

OPEN IN VIEWER

Thursday, August 9, 2012
12:00 pm	Registration: Turner Auditorium, Concourse Level
1:00 pm	Introduction and Welcome Address Dr. Dean Wong, Chair of the Organizing Committee and Dr. Gwenn Smith, Co-Chair
1:07 pm	Special Welcome to NRM12 Attendees Solomon Snyder, M.D., Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, and Chair Emeritus, Department of Neuroscience, Johns Hopkins University
1:15 pm	Young Scientist Bursary Awards Announcement Dr. Gwenn Smith, Co-Chair of the Organizing Committee
1:20 pm	Opening Remarks – Brain in the Dome: Back to the Future of Mapping Neuroreceptors at Work Professor Albert Gjedde, Aarhus University and University of Copenhagen, Denmark; McGill University, Canada; Johns Hopkins University, USA
Session 1 Mapping Dopamine Receptors at Work
	Moderators: Gerhard Gründer, Aachen University, Germany and Rajesh Narendran, University of Pittsburgh, USA
2:00 pm	O1: Changes in Striatal Dopamine in Response to IV Alcohol in Nontreatment-Seeking Alcoholics but Not Social Drinkers Dr. Karmen Yoder, Indiana University Center for Neuroimaging, Indiana University School of Medicine, USA
2:18 pm	O2: Relationships of D1- and D2-Like Receptor Availability and Response Inhibition in the Stop-Signal Task: A Preliminary PET Study Ms. Chelsea Robertson, Department of Molecular and Medical Pharmacology, University of California at Los Angeles, USA
2:35 pm	O3: Diurnal Changes in the Available Dopamine D2/D3 Receptor Density Suggests Decreased Intrasynaptic Dopamine at Night Dr. Hiroto Kuwabara, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, USA
2:53 pm	O4: The Relation between Body Mass Index and Dopamine D2 Receptor Availability in the Caudate: A PET Study in Humans Ms. Danielle Z. Bolling, Interdepartmental Neuroscience Program, Yale University, USA
3:10 pm	Break
3:30 pm	Plenary Lecture I – Dopamine and Loss Aversion: A Link to Impulsivity? Dr. Alain Dagher, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Canada
4:30 pm-	Poster Session I
6:00 pm	Turner Auditorium, Concourse Level
7:00 pm	Welcome Reception and Dinner: Top of the World, World Trade Center, Baltimore Inner Harbor
Friday, August 10, 2012
Session 2 Novel Radiotracers for Brain Mapping
	Moderators: Christer Halldin, Karolinska Institutet, Sweden and Yu-Shin Ding, New York University School of Medicine, USA
8:00 am	O5: Evaluation of a Small Library of Carbamates and Ureas, including PF-04457845, as Potential Imaging Agents for Fatty Acid Amide Hydrolase (FAAH) Dr. Alan Wilson, Centre for Addiction and Mental Health, University of Toronto, Canada
8:18 am	O6: Human PET Imaging with [11C]JNJ-42491293, a Tracer for the mGluR2 Positive Allosteric Site Dr. Mark Schmidt, Janssen Pharmaceutica N.V., Belgium
8:35 am	O7: A Novel PET Radiotracer for Imaging the Kappa Opioid Receptor Dr. Ming-Qiang Zheng, PET Center, Yale University, USA
8:53 am	O8: [11C]Elacridar, a PET Radiotracer to Measure the Function of P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier: First Assessment in Healthy Human Subjects Dr. Martin Bauer, Department of Clinical Pharmacology, Medical University of Vienna, Austria
9:10 am	Break
Session 3 Pathophysiology of Inflammation
	Moderators: Martin Pomper, Johns Hopkins University, USA and Robert Innis, National Institute of Mental Health, USA
9:30 am	O9: Validation of SUV as an Outcome Measure of [11C]PBR28 in Rat Using PET/MRI Dr. Janine Doorduin, Karolinska Institutet, Department of Clinical Neuroscience, Sweden; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, The Netherlands
9:48 am	O10: Correcting for the Ala147Thr Polymorphism in the Gene for 18 kDa Translocator Protein Improves Quantification of This Inflammatory Biomarker with [11C]PBR28 Dr. William Kreisl, Molecular Imaging Branch, National Institute of Mental Health, USA
10:05 am	O11: [18F]PBR111 Binding in Multiple Sclerosis: Relationship to Age and Clinical Variables Dr. Alessandro Colasanti, Imperial College London, UK
10:23 am	O12: Imaging Activated Microglia in Parkinson's Disease: A PET Study with a Novel Radiotracer, [18F]FEPPA Dr. Ji Hyun Ko, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada; Toronto Western Hospital and Research Institute, University of Toronto, Ontario, Canada
10:40 am	Plenary Lecture II – Molecular Imaging in Drug Addiction Dr. Nora Volkow, Director, National Institute on Drug Abuse, National Institutes of Health, USA
11:40	Lunch: Turner Auditorium, Concourse Level
12:40 pm	Workshop I – Cognitive Effects on Neurotransmission: How Strong is the Evidence? Conveners: Karen Faith Berman, National Institute of Mental Health, National Institutes of Health, USA and Edythe London, University of California at Los Angeles, USA
Session 4 Cannabinoid Mechanisms in Addiction and Neuropsychiatric Disorders
	Moderators: Koen Van Laere, Nuclear Medicine KU Leuven, Belgium and Andrew Horti, Johns Hopkins University, USA
1:40 pm	O13: Low Brain CB1 Receptor Occupancy by a Second Generation CB1 Antagonist TM38837 in Comparison with Rimonabant in Nonhuman Primates Dr. Akihiro Takano, Department of Clinical Neuroscience, Center for Psychiatric Research and Education, Karolinska Institutet, Sweden
1:58 pm	O14: The Use of [11C]OMAR and Positron Emission Tomography to Investigate the Pathophysiology of Posttraumatic Stress Disorder Mr. Christopher Bailey, Johns Hopkins University School of Medicine, USA
2:15 pm	O15: Mapping CB1 Cannabinoid Receptors with [3H]OMAR in the Flinders Rodent Model of Depression Dr. Adjmal Nahimi, Department of Nuclear Medicine and PET Centre, Aarhus University Hospitals, Aarhus University, Denmark; Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
2:33 pm	O16: Reduced Cannabinoid CB1 Receptor Binding in Alcohol Dependence Measured with Positron Emission Tomography Dr. Jussi Hirvonen, Molecular Imaging Branch, National Institute of Mental Health, USA
2:50 pm	Break
Session 5 Advances in Imaging the Glutamate System
	Moderators: Jeffrey Rothstein, Johns Hopkins University, USA and Edilio Borroni, F. Hoffmann-La Roche Ltd, Switzerland
3:10 pm	O17: PET Imaging of the Excitatory Amino Acid Transporter 2 in an Amyotrophic Lateral Sclerosis Rat Model Dr. John Gerdes, Biomedical and Pharmaceutical Sciences, University of Montana, USA
3:28 pm	O18: Metabotropic Glutamate Receptor 5 Radioligand [11C]ABP688 and N-Acetylcysteine Challenge in Rhesus Monkeys Ms. Christine Sandiego, Department of Biomedical Engineering, Yale University, USA
3:45 pm	O19: Tracer Kinetic Modeling of [11C]JNJ42491293, a PET Ligand for the mGluR2 Receptor in the Human Brain Dr. Michel Koole, Nuclear medicine KU Leuven, Belgium
4:03 pm	O20: PET Imaging of the Metabotropic Glutamate Receptor Type 5 in Cocaine Abuse Dr. Diana Martinez, Columbia University/NYSPI, USA
4:20 pm	Workshop II – Outcome Measures: How Many and How Different? Conveners: Albert Gjedde, Aarhus University and University of Copenhagen, Denmark; McGill University, Canada; Johns Hopkins University, USA and Hiroto Kuwabara, Johns Hopkins University, USA
5:20 pm-	Poster Session II
6:50 pm	Turner Auditorium, Concourse Level
Saturday, August 11, 2012
Session 6 Novel Applications of Serotonin Imaging
	Moderators: J. John Mann, Columbia University/NYSPI, USA and Gwenn Smith, Johns Hopkins University, USA
8:00 am	O21: Examination of Structural Connectivity in Depression: Anti-Depressant Remitters versus Non-Remitters Dr. Christine DeLorenzo, Columbia University, USA
8:18 am	O22: Treatment Response in Major Depression Predicted by Serotonin Transporter Interplay Professor Rupert Lanzenberger, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
8:35 am	O23: PET Imaging of Serotonin Transporter in Monkeys: Effects of Maternal Separation, and Long-Term Fluoxetine Treatment during Adolescence Mr. Saurav Shrestha, National Institute of Mental Health, National Institutes of Health, USA
8:53 am	O24: Serotonin-1A Receptor-Dependent Modulation of the Default Mode Network Mr. Andreas Hahn, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
9:10 am	Break
Session 7 Reference Plots: Issues and Solutions
	Moderators: Roger Gunn, Imanova Limited, UK and Yun Zhou, Johns Hopkins University, USA
9:30 am	O25: Estimation of the Linearity Point in Graphical Analysis Professor R. Todd Ogden, Columbia University/NYSPI, USA
9:48 am	O26: Limitations of SRTM, Logan Plot, and Equilibrium Analysis for Measuring Transient Dopamine Release in [11C]Raclopride PET Studies Ms. Jenna M. Sullivan, Yale PET Center, Yale University, USA
10:05 am	O27: Validation of the Partial Saturation Approach for In Vivo Quantification of Striatal Dopamine D2 Receptors with [11C]Raclopride Ms. Catriona Wimberley, Brain and Mind Research Institute and Faculty of Health Sciences, University of Sydney, Australia
10:23 am	O28: Update: Inhibition Plots of [11C]Yohimbine Binding Yield Consistent Estimates of Non-Displaceable Volumes of Distribution in Multiple Tests Professor Albert Gjedde, Aarhus University and University of Copenhagen, Denmark; McGill University, Canada; Johns Hopkins University, USA
10:40 am	Workshop III – Reward Deficiency Disorders: Do They Really Exist? Conveners: Robert Kessler, Vanderbilt University, USA and Alexander Hammers, Neurodis Foundation, Lyon, France
11:40 am	Lunch: Turner Auditorium, Concourse Level
12:40 pm	Workshop IV – Radiotracer Development as Tools for Target Validation: What Are the Critical Issues? Conveners: Linda Brady and William Potter, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Session 8 Interpreting In Vivo Amyloid Imaging
	Moderators: Chet Mathis, University of Pittsburgh, USA and Anton Forsberg, Karolinska Institutet, Sweden
1:40 pm	O29: The Detectability of Aβ Amyloid by Florbetapir F18 PET Imaging in Mouse Models of Alzheimer's Disease with Different Rates of Plaque Accumulation Dr. Alena Savonenko, Johns Hopkins University School of Medicine, USA
1:58 pm	O30: [11C]PiB PET and Post-mortem Measures of Amyloid Load: Regional Correspondence Dr. Julie C. Price, Department of Radiology, University of Pittsburgh, USA
2:15 pm	O31: Quantitative Assessment of Longitudinal Amyloid Imaging using [11C]PIB: Impact of Flow Variations Professor Ronald Boellaard, VU University Medical Center, The Netherlands
2:33 pm	O32: Combined CBF and Binding Analyses with Single 11CPIB PET Session in Alzheimer's Disease and Healthy Controls Dr. Anders B. Rodell, Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Denmark
2:50 pm	Break
3:10 pm	Plenary Lecture III – Neurodegeneration: Novel Findings and Pathways Professor Berislav Zlokovic, Chair, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, USA
4:10 pm	NRM2014 Conference Presentations Dr. Dean Wong, Chair of the Organizing Committee
4:45 pm-	Poster Session III
6:15 pm	Turner Auditorium, Concourse Level
6:15 pm	End of Sessions
8:00 pm	Conference Banquet and Closing Ceremony, Hyatt Regency Baltimore on the Inner Harbor