A case report of monozygotic (MZ) twins with Crouzon syndrome was previously published to highlight variables in clinical presentation. The postnatal and epigenetic causes for this variation are not well understood. An 8-year follow-up discusses their pertinent clinic course with consideration of genetic and nongenetic variables. The phenotypic and symptomatic obstacles encountered since their initial assessment are reviewed, and the use of three-dimensional Medical Modeling (Golden, CO) as a preoperative planning strategy is addressed. Analyzing the longitudinal clinical course of MZ twins with syndromic craniosynostosis will help better predict and provide optimal treatment.
SherSColePKaufmanYHatefDAHollierLCraniosynostotic variations in syndromic, identical twinsAnn Plast Surg20086103290–293
2.
LakinGESinkinJCChenRKoltzPFGirottoJAGenetic and epigenetic influences of twins on the pathogenesis of craniosynostosis: a meta-analysisPlast Reconstr Surg201212904945–954
3.
GrahamJMJrSmithDWMetopic craniostenosis as a consequence of fetal head constraint: two interesting experiments of naturePediatrics198065051000–1002
4.
LoffredoASammartinoAde CrecchioGCrouzon disease in twins. Clinical and pathological contributionOphthalmologica197717506297–304
5.
DavidDJCooterRDEdwardsTJCrouzon twins with cloverleaf skull malformationsJ Craniofac Surg199120256–60, discussion 61
6.
YasudaSEnomotoTYamadaYNoseTIwasakiNCrouzon disease associated with sinus pericranii: a report on identical twin sistersChilds Nerv Syst1993902119–122
7.
Williamson-KruseLBieseckerLGPfeiffer type cardiocranial syndrome: a third case reportJ Med Genet19953211901–903
8.
FranceschiniPLicataDGualaA, et al. Long first metacarpal in monozygotic twins with probable Baller-Gerold syndromeAm J Med Genet19988004303–308
9.
LajeunieEBonaventureJEl GhouzziVCatalaMRenierDMonozygotic twins with Crouzon syndrome: concordance for craniosynostosis and discordance for thumb duplicationAm J Med Genet20009102159–160
10.
BenjaminLTTrowersABSchachnerLASuccessful acne management in Apert syndrome twinsPediatr Dermatol20052206561–565
11.
FunatoNNohtomi-OhyamaJOhyamaKMonozygotic twins concordant for Crouzon syndromeAm J Med Genet A2005133A02225
12.
KleintjesWGCraniofacial abnormalities in twins at Tygerberg hospital, craniofacial unitJ Craniofac Surg20051601169–171
13.
BreugemCCFitzpatrickDFVerchereCMonozygotic twins with Apert syndromeCleft Palate Craniofac J20084501101–104
14.
EscobarLFHiettAKMarnochaASignificant phenotypic variability of Muenke syndrome in identical twinsAm J Med Genet A2009149A061273–1276
15.
KohanELongakerMTNguyenJ, et al. Pfeiffer syndrome twins: despite improved correction in one twin, growth disturbance results in similar need for subsequent monobloc advancementJ Craniofac Surg20092003811–815
16.
PaiLKohoutMPMullikenJBProspective anthropometric analysis of sagittal orbital-globe relationship following fronto-orbital advancement in childhoodPlast Reconstr Surg1999103051341–1346
17.
Raposo-AmaralCERaposo-AmaralCMRaposo-AmaralCAChahalHBradleyJPJarrahyRAge at surgery significantly impacts the amount of orbital relapse following hypertelorbitism correction: a 30-year longitudinal studyPlast Reconstr Surg2011127041620–1630
