A Neuromagnetic View of the Human Visual Brain

A visual stimulus typically activates several cortical areas, both sequentially and overlapping in time. Characterisation of this temporal activation sequence has significantly improved with the recent development of whole-scalp neuromagnetometers. The magnetoencephalographic (MEG) signals mainly arise from time-locked cortical activity. Although the spatial localisation of several simultaneously active areas is ambiguous because of the non-uniqueness of the inverse problem, the comparison of estimated source regions across observers and utilisation of previous functional knowledge can usually resolve this ambiguity. Visual object naming, for example, generates cortical activation progressing bilaterally from occipital to temporal and frontal lobes. Simultaneously, the parieto-occipital alpha rhythm dampens as a function of task demands. Similarly, this rhythm is at a lower level after objects than non-objects in an object-detection task, which suggests that the parieto-occipital area is active when attending to visual form. In addition, this area generates evoked responses after voluntary blinks, saccades, and luminance increments, which in turn suggests that it participates in the updating of visual percepts.

The sources of extrastriate MEG signals are generally in good agreement with the location of activation found with other imaging methods: visual motion activates the V5 in the ascending limb of the inferior temporal sulcus, faces the ventral temporo-occipital cortex, and objects the lateral occipital (LO) regions. Interestingly, the strength of the right LO activity closely follows the proportion of correctly detected objects. The future neuromagnetic studies will focus not only on functional localisation of the active areas, but also on how the brain processes various stimuli.