The Number of CD34 + Cells Mobilized into the Peripheral Blood Can Predict the Quality of Subsequent Collections

PBPC were mobilized using a variety of chemotherapy regimens plus G-CSF in a group of 126 consecutive patients. Data are presented that show a close correlation between the number of CD34⁺ cells mobilized into the peripheral blood (PB) and the number of CD34⁺ cells subsequently collected by leukapheresis (R = 0.904). On the basis of this correlation, a regression formula was calculated that could give an estimate of the total number of CD34⁺ cells likely to be collected by leukapheresis from a given number of CD34⁺ cells per microliter PB. An easy-to-read table has been compiled to show how this type of analysis can be applied to predict the likely dose of CD34⁺ cells that will be obtained by leukapheresis over a wide range of patient weights.