Abstract
Factors such as overnutrition, physical inactivity and ageing can trigger a chronic inflammatory state that results in metabolic diseases such as type 2 diabetes, atherosclerosis, and coronary heart disease. The response to this loss of nutrition and energy homeostasis is a low-grade chronic inflammatory state associated with impaired insulin action. This will eventually result in type 2 diabetes in genetically and metabolically predisposed individuals. The chronic inflammatory state can also affect the vasculature resulting in endothelial dysfunction, atherosclerosis, peripheral arterial disease and other macro and micro vascular complications.
Inflammatory disorders are of special relevance at this time given the influence of type 2 diabetes and the induced cytokine storm on COVID-19 outcomes and an increasing interest in the manipulation of inflammatory pathways to influence the course of metabolic disease.
We would be especially interested in work that integrates different information sources including the following
one or multiple in vitro and in vivo methodologies,
computerised and in silico systems,
artificial intelligence
exposure and/or kinetics modelling
systematic reviews
clinical data
OMICS
Microbiome studies
If you are interested to publish your work in this upcoming Metabolic Syndrome special issue, please submit your manuscript here by February 1, 2021.
We look forward to taking into consideration your work for our upcoming special issue.