P01.17
Purpose: This study evaluated the effect of far infrared emitted by bioceramics in a BioPowerTM Bioceramics Pad against mechanical and thermal hyperalgesia as well as paw temperature increase and edema formation in a mice model of inflammatory pain.
Methods: Experiments were conducted with male Swiss mice (30–35g) after approval of the University of South of Santa Catarina Ethics Committee. The animals underwent intraplantar injection of Freud's complete adjuvant (CFA, 20 μl - 70%) and for treatment a BiopowerTM Bioceramics Pad (80% BioCorn PVC - 20% Bioceramic materials) was placed inside the animals box. After 24 h of exposure to the product, mechanical and thermal hyperalgesia was assessed as response frequency to 10 presentations of a 0.4g von frey filament or by hot stimuli applied to the animals right hind paw (Hot Plate Method). Evaluations were performed daily for 10 days. After evaluation the animals were placed in their boxes and re-exposed to the Pad until the subsequent evaluation (24 hours later). In addition, edema formation and hind paw temperature were evaluated on experimental days 1, 3 and 10 with a micrometer and a digital thermometer, respectively. Control animals were placed on a Sham Pad (100% BioCorn PVC without bioceramics) and underwent the same experimental protocol.
Results: Acute exposure to the BioPowerTM Bioceramics Pad induced analgesia which lasted for 2 hours (P<0.001 - maximum inhibition of 53±11%). Chronic treatment reduced mechanical hyperalgesia on all evaluation days and thermal hyperalgesia on days 1 and 3. In addition, the treatment decreased paw temperature on days 1 and 3, 8±1% (P<0.001) and 5±1% (P<0.05) but did not affect edema formation.
Conclusion: Far Infrared emitted by a BioPowerTM Bioceramics Pad reduced mechanical and thermal hyperalgesia of inflammatory origin as well as paw temperature increase induced by intraplantar injection of CFA in mice.
Contact: Daniel Fernandes Martins, danielmartinsfisio@hotmail.com
