Abstract
Objective:
This narrative review discusses several studies that demonstrated the effect of self-care acupressure, especially on maternal-health problems in antenatal, labor, and postpartum times, as well as the mechanism of acupressure, the points used, and treatment strategies to support the Sustainable Development Goals (SDGs) program in the health sector.
Methods:
PubMed and Google Scholar were searched for randomized controlled trials and systematic reviews/meta-analyses from the date of their inception to February 2022.
Results:
The 14 studies that were included showed the possibility that acupressure could have a positive impact on maternal health. This self-care can be the main alternative in overcoming the gap in solving health problems in the world.
Conclusions:
Self-care acupressure at various acupoints has been shown to be feasible to reduce problems during antenatal, labor, and postpartum times. Additional research on the use of acupressure during pregnancy and cross-sectional collaboration to increase the awareness of acupressure techniques are needed.
INTRODUCTION
The United Nations (UN) has planned a global action to be achieved by 2030. The action is a program called Sustainable Development Goals (SDGs), which has 17 scopes to end poverty, inequality, and protect the environment. 1 With respect to health, the UN has planned SDG 3: “Ensuring a Healthy Life and Promoting Well-Being for All Ages,” which is a goal that has a broad scope and is connected to other SDG scopes. 2 SDG 3 also emphasizes universal health coverage in the context of efforts for equitable distribution of health throughout the world. This article focuses on parts 3.7, and 3.8 of SDG 3. These parts are designed to ensure sexual- and reproductive-health care services along with universal health coverage, including protection from financial risk; access to quality essential health-care services; and access to safe, effective, quality, and affordable essential medicines and vaccines for all people. 3
Sexual and reproductive health and rights emphasize 5 important aspects in the Global Reproductive Health Strategy, including improving antenatal, delivery, postpartum, and newborn care; providing high-quality services for family planning, including infertility services; eliminating unsafe abortion; combating sexually transmitted infectious, and promoting sexual health. 4 In 2017, it was estimated that 810 women in the world died every day due to complications related to pregnancy and childbirth. 5 In developing countries, such as Indonesia, the maternal mortality rate in 2015 reached 305 per 100,000 live births. 6 Most of the causes of this high maternal-mortality rate can actually be prevented and arise due to low resources. 5
The main obstacle to SDG 3 in the world is the uneven distribution of health workers, infrastructure, geographical locations, and technology. One of the efforts to overcome this problem is to foster self-care for the community. Self-care interventions are among the most-promising and exciting new approaches to improving health and well-being, both from a health-systems perspective and for people who might use these interventions. Self-care is the ability of individuals, families, and communities to promote health, prevent disease, maintain health, and to cope with illness and disability with or without the support of a health-care provider. 7
One of the options for self-care is acupressure, a technique of applying pressure to acupoints, using a fingertip or device with a duration of 2–3 minutes per acupoint. 8 In the area of sexual and reproductive health, there are many studies on acupressure as a therapy that treats symptoms. This therapy tends to be safe and noninvasive, and can be applied easily by the general public. 9
It is necessary to distinguish between acupressure and acupuncture. Acupressure is a noninvasive alternative therapy with similar therapeutic principles as acupuncture, but without needle insertions. 10
Melzack and Wall introduced the Gate Control Theory to explain the mechanism of action of acupressure. 11 Pressure on the acupuncture points induces brain stimulation 4 times faster than pain stimulation. The continuous impulses will cause the nerve gates to close and increase the body's pain threshold. Acupressure also activates small myelinated nerves in the muscles and transmits this stimulation to higher nerve levels. The biochemical mechanisms of acupressure lead to complex neurohormonal responses, causing an increase in cortisol production and inducing a relaxation response. In addition, there is also modulation of physiologic responses by increasing transmission of endorphins and serotonin to the brain and specific organs. Myelinated neural fibers are activated and stimulate the hypothalamus and pituitary gland, causing release of b-endorphins from the hypothalamus into the spinal fluid and the pituitary gland, and into the blood, respectively, by activating an acupuncture point. Thus, the analgesic and sedative effect of b-endorphins facilitates normal respiratory function of the patient. 11
Acupressure can also enhance physical performance and overcome fatigue by mediating nitric oxide (NO)–signaling, which is known to improve local microcirculation via cyclic guanosine monophosphate. 12
Acupressure has been shown to be a feasible form of self-care therapy. This is in line with the SDG 3 to be achieved in 2030, which focuses on self-care. This literature review discusses the benefits of self-care acupressure, especially for maternal health in antenatal, labor, and postpartum times.
METHODS
PubMed and Google Scholar were searched, from the date of their inception to February 2022, for randomized controlled trials (RCTs) and systematic reviews/meta-analyses. The search was limited to studies published in English using the key terms

Search strategy scheme.
RESULTS
The literature search described in the Methods section yielded 1613 studies in the initial search. After screening, 14 studies met the inclusion criteria for this literature review. However, for postpartum hemorrhage, the study chosen was about acupuncture because there were no studies related to acupressure on postpartum hemorrhage. In theory, a similar effect can also be achieved by applying pressure to the same acupuncture points. Table 1 provides details on the 14 included studies.
Summary of the 14 Included Studies
SMD, standardized mean difference; d, day(s); min, minute(s); hr, hour(s); PUQE: Pregnancy-Unique Quantification of Emesis; LOS, length of stay; CI, confidence interval; LBP, low-back pain; wk, wk(s); ISI: Insomnia Severity Index; RCTs, randomized controlled trials; sec, seconds; SBP, systolic blood pressure, DBP, diastolic blood pressure; BP, blood pressure; MD, mean difference; EA, electroacupuncture; i.v., intravenous.
DISCUSSION
Acupressure for Antenatal Problems
Nausea and vomiting
Nausea and vomiting are the most-common problems in pregnancy. Approximately 50%–80% of women reported this happening between 6 and 12 weeks of pregnancy. Twenty percent of cases can persist until the twentieth week of pregnancy.13–15 Some women experience frequent and severe nausea, known as hyperemesis gravidarum. 14
Pressure stimulation at PC-6 is effective for treating nausea and vomiting. PC-6 is located on the anterior aspect of the forearm, between the 2 tendons, 3.1 fingerbreadths proximal to the wrist.10,16
Mobarakabadi et al., recruited 75 pregnant women with a gestational age of under 20 weeks who experienced mild and moderate nausea and vomiting. 13 The study compared the effect of PC-6 acupressure using a Sea-Band® bracelet versus placebo and a control condition. After 3 days of the intervention, there was a significant reduction in the frequency, duration, and severity of nausea and also in the frequency of vomiting (all P < 0.001). 13
Another trial on 90 women with singleton pregnancies that were earlier than 12 weeks was conducted by Tara et al, in 2020. 14 The patients were randomized into 3 groups of (1) PC-6 acupressure, (2) sham acupressure, and (3) medication with vitamin B6 and metoclopramide. PC-6 acupressure was applied for 10 minutes 4 times per day. A Rhodes Index was used to measure nausea, retching, and vomiting frequency; distress from nausea, retching, and vomiting; and the amount of vomiting. After the intervention, there was significantly different severity outcomes in the 3 groups. 14
In 2017, Adlan et al. conducted a trial that included 120 women with singleton pregnancies, who were randomized into 2 groups. 10 In the intervention group, acupressure was applied, using a wristband placed on PC-6 for 12 hours per day for a total 3 days. The researchers concluded that pressing PC-6 reduced the symptoms of nausea and vomiting and the value of ketonuria in the treatment group, compared to the placebo group. 10
Low-back pain in pregnancy
Low-back pain (LBP) in pregnant women is one of the main complaints experienced during pregnancy. It is estimated that more than 50% of pregnant women experience LBP. Despite its prevalence, it is considered to be a normal phenomenon experienced in pregnancy. 17 The exact cause of LBP in pregnancy is difficult to understand because LBP is considered to be multifactorial and is associated with biomechanical, vascular, and hormonal changes. 18
Acupressure is one of the nonpharmacologic options for treating LBP. Acupoints used to treat LBP are BL-40, GB-30, BL-57, BL-25, GB-34, BL-60, BL-54, BL-37, and BL-23. In a 2021 study, 19 acupressure was superior to tu'ina massage on response rate (relative risk [RR]: 1.25; 95% confidence interval [CI]: 1.16, 1.35; P < 0.00001) and in the standardized mean difference (SMD) for pain reduction (SMD: −1.92; 95% CI: −3.09, −0.76; P = 0.001). Likewise, acupressure was superior to physical therapy (SMD: −0.88; 95% CI: −1.10, −0.65; P < 0.00001) and to usual care (SMD: −0.32; 95% CI: −0.61, −0.02; P = 0.04] for pain reduction. The patients' Oswestry Disability Index scoring was improved significantly by acupressure, compared with usual care (SMD: −0.55; 95% CI: −0.84, −0.25; P = 0.0003). The combination of acupressure with either manual acupuncture or electroacupuncture (EA) produced significant improvements over adjuvant therapies alone in RR (RR: 1.19; 95% CI: 1.13, 1.26; P < 0.00001), pain reduction, and Japanese Orthopaedic Association score. 19
Mood disorder
Pregnancy conditions accompanied by mental-health problems and other problems can harm a mother and her child. In addition, other problems faced during the antenatal time—such as a stigma in society, a feeling of inadequacy, low self-efficacy, and negative perceptions—will influence mothers to come to health facilities. 20 Mental-health problems, including prenatal stress, can affect infant health indirectly. This condition also affects development by increasing the risk of adverse birth outcomes, which are, in turn, associated with substantial developmental and health consequences. 21
Pharmacotherapies, such as benzodiazepines and nonbenzodiazepines, are associated with abuse and dependence, and have uncertain efficacy with long-term use. Some studies indicated that acupressure on HT-7 improved patients' sleep quality and increased their melatonin levels.
A study with acupuncture produced good results for treating mood disorders. In theory, the same effect should occur with acupressure, although no studies have been completed with the points used in acupuncture research. CV-12 needling in healthy subjects was mentioned in a study with functional magnetic resonance imaging (fMRI). There are mechanisms for modulating the limbic–prefrontal functional network that overlap with the functional circuits associated with emotional and cognitive regulation. Needle insertion in PC-6 has been shown to reduce heart rate (HR) and systolic blood pressure (SBP) in healthy subjects (cited in a study by Lin et al. on acupressure), suggesting a sympathoinhibitory effect. 22
A study of EA in GV-20 and SP-6 in chronically stressed rats increased the binding site of 5-HT1A receptors in the hippocampus of depressed rats and significantly increased the activities of 5-HT. This study also showed significant increases in serum levels of norepinephrine and dopamine. Furthermore, Lin et al. noted, in an acupressure study, that acupuncture at GV-20 and Ex-HN-3 combined with 5-HT reuptake inhibitors in older adults with depression significantly increased serum brain-derived neurotrophic factor (BDNF) levels. 23 Acupuncture points used included GV-20, GB-20, PC-6, HT-7, CV-12, and KI-1 at a frequency of 40–60 times per minute for 1–2 minutes.
The majority of studies used more than 3 acupoints, but the commonest acupoints used for treating depression are ST-36, SP-6, and HT-7, with 30–45 minutes per session and 2–40-week durations. 23 However, SP-6 is secondary segmentation related to the uterus. Caution is necessary when using SP-6 in women at 36 weeks of gestation or less.
Preeclampsia
Preeclampsia is defined as a severe pregnancy-associated disease with the occurrence of hypertension and proteinuria at 20 weeks' gestation in a previously healthy pregnant woman and is associated with high maternal and fetal morbidity and mortality worldwide. High blood pressure (BP) in pregnant woman is one of the risk factors for preeclampsia. 24 In a trial conducted by Lin et al., acupressure lowered SBP and diastolic BP in patients with hypertension. 25 Acupressure was applied at LR-3, which is located on the dorsum of the foot in the distal hollow at the junction of the first and second metatarsal bone. The pressure was applied for 3 minutes. 25
Another trial on acupressure for treating BP was conducted by Mardiyanti et al. 26 This trial tested the effectiveness of Jin Shin Jyutsu (JSJ) massage and acupressure at LR-3 and LR-2 for reducing BP of pregnant mothers with preeclampsia. JSJ is a gentle noninvasive form of energy practice that utilizes 26 sets of key locations, called Safety Energy Locks, to promote the body's self-healing mechanism. The exact mechanism is not yet known.
A study by Millspaugh et al. in 2021 showed that JSJ was a viable option for reducing stress. 27 Pressure at LR-2 and LR-3 stimulated the sensory nerve cells around the acupoints, which produced endorphin through the hypothalamic–pituitary–adrenal axis. This endorphin hormone induces a sense of calm and comfort that contributes to the change of BP.
A functional magnetic resonance imaging study in healthy adults showed that stimulating LR-3 and LR-2 with acupuncture produced deactivation of the limbic–paralimbic neocortical network, suggesting that acupressure on that acupoints might also work in the same way. 28 Another trial found that acupressure at LR-3 and LR-2 combined with JSJ massage effectively reduced BP in pregnant mothers with preeclampsia. 26
Acupressure For Labor Induction and Pain Management
Labor pain occurs from uterine contractions, cervical dilatation, and tension in the vaginal area and pelvic floor. Labor pain can cause stress and fear, and have a negative effect on the health of the mother, fetus, and newborn if the pain is left untreated. The stress and fear caused by excessive labor pain can cause peripheral vasoconstriction, reducing blood flow to the placenta, leading to negative fetal health. Even worse, labor pain can lead to a longer time to delivery with resultant health risk to the fetus. 29
In addition, the fear and anxiety during birth may reduce a pregnant women's self-confidence, causing her to lose control, and also cause tension in the pelvic muscles. This tension causes resistance to the pushing forces applied by the uterus and the laboring woman. Thus, labor pain induces more pain, prolongs labor time is, and endangers the health of the fetus. 29
Although evidence supports the efficacy of pharmacologic methods of treatment, potential adverse effects have also been identified. For example, parenteral opioids may lead to neonatal respiratory depression, hemoglobin desaturation, uterine hyperactivity, and an abnormal fetal HR. Inhalational analgesics can cause nausea, vomiting, mask phobia, and drowsiness. Systematic reviews have indicated that women receiving epidural analgesia were more likely to experience hypotension, motor blockade, intrapartum fever, and urinary retention. 29
Evidence suggests that acupuncture and acupressure may be effective for managing pain in labor and birth, and may help to reduce rates of medical intervention, and the associated morbidity and mortality reported in reviews of maternity services. The evidence for acupuncture and acupressure has focused on assessing the efficacy of the interventions on pain relief and the supportive role of these interventions for women during labor. Acupressure for induction techniques may be practiced lightly starting at 37 weeks.29,According to Levett et al., antenatal education on—and the use of—complementary medicine techniques during labor, including acupressure, visualization, and relaxation, can manage pain effectively, increase personal control for women during labor, and reduce medical interventions including epidural use and cesarean section.30,31
The mechanism by which acupressure reduces labor pain may be related to reduction in adrenaline and noradrenaline release, and to vasodilation, which, in turn, results in oxytocin and endorphin release. In addition to the direct pain-relieving effects of endorphins and oxytocin, the improved contractions from increased oxytocin release can improve the efficacy of uterine contractions and shorten the duration of labor.
Points used are SP-6 and LI-4. It has been reported that SP-6 has a specific effect of increasing the strength of uterine contractions and shortening length of the first stage of labor, while LI-4 is a pain reliever. 32 SP-6 plays a role in stimulating release of oxytocin from the pituitary gland, so its effect will be seen in the decreased requirement for synthetic oxytocin and length of labor. Natural oxytocin is known to have a relaxing effect, therefore pain scores are also affected, while LI-4 is known to have an effect on natural opioid release. The effect may be best reflected in pain scores (subjectively), or in reduction of epidural analgesia or other conventional analgesia (objectively). 32
Acupressure for Postpartum Problems
Postpartum hemorrhage
According to American College of Obstetrics and Gynecology, postpartum hemorrhage is defined as a loss of blood >1000 mL with signs and symptoms of hypovolemia within 24 hours after delivery, regardless of the route of delivery. This event is the cause of one-fourth of maternal deaths worldwide. Definitive management of postpartum hemorrhage can become another obstacle if there are inadequate facilities and infrastructure, such as in a vast country with an uneven distribution of health access. In accordance with the target of SDGs 3, which emphasizes self-care, acupressure can be one of the nonpharmacologic prevention efforts for curbing postpartum hemorrhage.
López-Garrido et al., conducted an RCT of 76 puerperal women who had normal spontaneous births. 33 These patients were divided into 2 groups: (1) verum acupuncture and (2) sham acupuncture. The researchers evaluated the influence of acupuncture on the third stage of labor. The acupoint used in this trial was CV-6, and manual acupuncture was used. Stimulation on CV-6 was effective for decreasing placental expulsion time and induced uterus contraction. Thus, the reduction in the length of the third stage of labor might reduce the risk of postpartum hemorrhage. 33
Another RCT, conducted by Liu et al., recruited 276 purpuerants who were having difficult labor. 34 The women were divided randomly into 2 groups: (1) medication + intravenous oxytocin and (2) medication + acupuncture. In the second group, acupuncture was given at bilateral LI-4, located in the middle of the second metacarpal bone on the radial side of the hand. The researchers concluded that stimulation at LI-4 was effective for promoting uterine contractions and shortening labor, avoiding complications. Acupuncture + medication was more effective and safe for both the mothers and their newborns. 34
These several studies have reported acupuncture being effective for inducing uterine contractions. In theory, a similar effect can also be achieved by applying pressure to the same acupuncture points. Thus, acupressure may be a therapeutic option for preventing postpartum hemorrhage. Further research is needed to assess the effectiveness of acupressure for inducing uterine contractions, as studies on acupuncture for this condition have not yet been conducted.
Breastfeeding
Breastfeeding is a vital part of providing every child with the healthiest start in life. This practice can benefit the infant and the mother. Breastfeeding is also the first baby vaccine and the best source of nutrition. 35
A systematic review on the effects of acupressure, acupuncture, and massage techniques on symptoms of breast engorgement and breast milk volume by Hajian et al. 36 included a study in Iran by Kamali Moradzade et al. 37 that reported that there was a significant decrease in mean of breast hyperemia scores in an acupressure versus a hot/cold compress group. The mean difference between before and after the interventions showed significant differences in both groups (P < 0.001). The differences were shown in the patients' right breasts (5.94 ± 2.48 versus 8.53 ± 2.48, respectively) and left breasts (5.5 ± 2.3 versus 7.79 ± 3.95, respectively) in acupressure and compress groups. 37
Acupressure also can increase the production of breast milk. Breast milk is considered to be the most important food for newborns and is highly recommended for them exclusively in the first 6 months of their lives. One of the reasons a mother stops breastfeeding her baby is inadequate breast milk. A study conducted by Sulymbona et al., 38 found that acupressure can increase breast milk production in postpartum mothers. The study included 70 postpartum mothers, 35 in an intervention group and 35 in a control group. The points used in this study were CV-17, ST-18 and SI-1. Acupressure on these acupoints stimulates beta-endorphin in the brain and spinal cord. Endorphins are useful for reducing pain, affecting memory and mood, which can then increase the prolactin hormone. 38
Risks of Acupressure in Pregnancy
Although acupressure tends to be safe to do, there are still risks with this therapy. The most-common risk is soreness and bruising at the acupoints after therapy, whereas an uncommon—but serious—risk in patients with serious cardiac problems could be a drop in BP leading to undesirable effects. Acupressure should be avoided after meals, alcohol consumption, or after taking narcotics. One should not perform acupressure on skin that is inflamed, injured, or scarred, or that has a rash.39,40
Acupressure in pregnancy, especially at points such as LI-4 and SP-6, needs special attention due to inducing in premature induction of labor if performed too soon.20,23
CONCLUSION S
Self-care is a reasonable approach for supporting SDG 3; and can be done by anyone, anywhere, and at any time. Acupressure is a potential self-care technique that has shown some promise for use during antenatal, labor, and postpartum times. Additional research on the use of acupressure during pregnancy and cross-sectional collaboration to increase awareness of acupressure techniques are needed.
Footnotes
AUTHOR DISCLOSURE STATEMENT
No financial conflicts of interest exist.
FUNDING INFORMATION
No funding was provided for this project.
