Polymorphisms in Candidate Genes and Lipodystrophy and Dyslipidemia

E ditor: I read the recent publication on the effect of polymorphisms in candidate genes and lipodystrophy and dyslipidemia with great interest. ¹ Marzocchetti et al. concluded that “Knowledge of the effect of genetic determinants on dyslipidemia and lipodystrophy may prompt the investigation of potential pathogenetic mechanisms and might eventually be used for guiding individualized treatment decisions.” ¹ I agree with the conclusion of the authors. However, I have some issues for discussion. First, the authors studied only a few subjects and this might not be a good statistical representative for general cases. Second, the authors studied a group of genes and identified the risk. Hence, the findings might be confounded by the other nonstudied genes. This might be the reason for some findings that are discordant with previous reports. ^2,3