Abstract
The Rosalind Franklin Society (RFS), in partnership with Mary Ann Liebert, Inc., publishers, enthusiastically congratulate our distinguished recipient of the 2024 annual
Nicole E. Wheeler, Sarah R. Carter, Tessa Alexanian, Christopher Isaac, Jaime Yassif, and Piers Millet, “Developing a Common Global Baseline for Nucleic Acid Synthesis Screening,” Applied Biosafety 29, no. 2 (June 2024): 71–78, https://doi.org/10.1089/apb.2023.0034.
Abstract
Introduction: Nucleic acid synthesis is a powerful tool that has revolutionized the life sciences. However, the misuse of synthetic nucleic acids could pose a serious threat to public health and safety. There is a need for international standards for nucleic acid synthesis screening to help prevent the misuse of this technology.
Methods: We outline current barriers to the adoption of screening, which include the cost of developing screening tools and resources, adapting to existing commercial practices, internationalizing screening, and adapting screening to benchtop nucleic acid synthesis devices. To address these challenges, we then introduce the Common Mechanism for DNA Synthesis Screening, which was developed in consultation with a technical consortium of experts in DNA synthesis, synthetic biology, biosecurity, and policy, with the aim of addressing current barriers. The Common Mechanism software uses a variety of methods to identify sequences of concern, identify taxonomic best matches to regulated pathogens, and identify benign genes that can be cleared for synthesis. Finally, we describe outstanding challenges in the development of screening practices.
Results: The Common Mechanism is a step toward ensuring the safe and responsible use of synthetic nucleic acids. It provides a baseline capability that overcomes challenges to nucleic acid synthesis screening and provides a solution for broader international adoption of screening practices.
Conclusion: The Common Mechanism is a valuable tool for preventing the misuse of synthetic nucleic acids. It is a critical step toward ensuring the safe and responsible use of this powerful technology.
Biosketch
Dr. Nicole Wheeler is a research group leader and technical consultant in biosecurity and computational biology. Her group develops computational methods for detecting emerging biological threats in cases ranging from directing individual patient care to steering global biosecurity surveillance frameworks. She is actively involved in shaping the governance of emerging technologies related to health security, advocating for responsible development and implementation.