Abstract
Tumors are composed of a heterogenous cell population alongside a vast array of chemical mediators, extracellular fluids and matrix proteins, which collective interact and form the tumor microenvironment (TME). The resultant TME has been shown to support not only neoplastic development and progression but also treatment resistance. Bioelectricity is involved in the normal functioning of the various cell populations and its disruption contributes to the deleterious effects of the TME on cancer.
This Special Issue focuses on the cellular architecture of the TME, in addition to cancer cells, in particular, stem, immune, stromal and endothelial cells. Intended manuscripts will aim at exploring the impact of aberrant bioelectrical signaling within the TME as a whole in promoting tumorigenesis. Articles should highlight the importance of bioelectric targets as potential novel personalized cancer therapeutics with a view to improving patient outcomes.
The guest editors would welcome original research articles, reviews, perspectives, technical notes and protocols that report on recent advances in the field. Areas of interest include, but are not restricted to:
Cancer development and progression Cancer stem cells Immune cells and signaling Stromal interactions Angiogenesis Ion channels, exchangers, pumps, receptors Cell signaling Extracellular matrix
Contributions will receive prompt and thorough peer review. Please refer to our Instructions for Authors at www.liebertpub.com/bioe before submitting your manuscript for consideration. Also, before submitting, authors would be welcome to discuss their ideas directly with Guest Editors Dr. Paul Buchanan (paul.buchanan@dcu.ie) and Prof. Christophe Vandier (christophe.vandier@univ-tours.fr).
Early submissions will receive prompt and thorough peer-review; accepted manuscripts will be published as e-pub ahead of print when-ready. This Special Issue is scheduled to appear in full online and in print in December 2022.
About the Journal
Bioelectricity is the only peer-reviewed journal dedicated to the study of the natural electricity within living organisms and how to harness this phenomenon to treat and cure disease. The Journal publishes ground-breaking multidisciplinary research and advances documenting this next step in the evolution of how we study life. For complete tables of content and a sample issue, please visit the Bioelectricity website, www.liebertpub.com/bioe.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Tissue Engineering, and The CRISPR Journal. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 90 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website, www.liebertpub.com.