The Yin and Yang of Adenosine Receptors: A Piquant Story

Davis M , Walker DL , Miles L , et al. Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology. 2010; 35:105–135.

Giménez-Llort L , Fernández-Teruel A , Escorihuela RM , et al. Mice lacking the adenosine A₁ receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. Eur J Neurosci. 2002; 16:547–550.

Simões AP , Machado NJ , Gonçalves N , et al. Adenosine A_2A receptors in the amygdala control synaptic plasticity and contextual fear memory. Neuropsychopharmacology. 2016; 41:2862–2871.

Pliássova A , Henriques M , Silva HB , et al. Control of NMDA receptor-mediated currents by adenosine A₁ and A_2A receptors within the basolateral amygdala. J Caffeine Adenosine Res. 2020; 10:61–70.

Fredholm BB , IJzerman AP , Jacobson KA , et al. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—An update. Pharmacol Rev. 2011; 63:1–34.

Schmidt J , Ferk P . Safety issues of compounds acting on adenosinergic signalling. J Pharm Pharmacol. 2017; 69:790–806.

Chen JF , Cunha RA . The belated US FDA approval of the adenosine A_2A receptor antagonist istradefylline for treatment of Parkinson's disease. Purinergic Signal, 2020. [Epub ahead of print]; DOI: 10.1007/s11302-020-09694-2.

Gomes CV , Kaster MP , Tomé AR , et al. Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration. Biochim Biophys Acta. 2011; 1808:1380–1399.

Ferré S , Ciruela F . Functional and neuroprotective role of striatal adenosine A_2A receptor heterotetramers. J Caffeine Adenosine Res. 2019; 9:89–97.

Rebola N , Lujan R , Cunha RA , et al. Adenosine A_2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron. 2008; 57:121–134.

De Petrocellis L , Nabissi M , Santoni G , et al. Actions and regulation of ionotropic cannabinoid receptors. Adv Pharmacol. 2017; 80:249–289.

Puntambekar P , Van Buren J , Raisinghani M , et al. Direct interaction of adenosine with the TRPV₁ channel protein. J Neurosci. 2004; 24:3663–3671.

Xiao Y , Chen X , Zhang PA , et al. TRPV₁-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. Sci Rep. 2016; 6:29026.