Abstract
This paper outlines recent developments in the field of natural orifice translumenal endosurgery (NOTES) in urology and nephrectomy from the perspective of a flexible endoscopist. The history of transvaginal extraction of kidney specimens using rigid laparoscopic instruments and early studies of transvaginal nephrectomy as a precursor of NOTES are reviewed. Transgastric approaches to nephrectomy using flexible instruments and transvesical hybrid approaches to nephrectomy and other intra-abdominal procedures including cholecystectomy and transvesical lung biopsy are outlined, as are other experimental approaches including transrectal kidney removal. The paper reviews the rationale for a NOTES approach to abdominal surgery and discusses recent human studies. The limitations of NOTES and need for better instrumentation and more studies are stressed.