Correction to: Indian Gooseberry and Barley Sprout Complex Prevent Oxidative Stress and Photoaging of the Skin in Ultraviolet B-Irradiated SHK-I Mice by Lee et al. Journal of Medicinal Food 2024;27(6):488–501;doi: 10.1089/jmf.2023.K.0229

RESULTS

The mRNA expression of collagen synthesis-related factors such as COL1A1, COL1A2, COL1A3, and COL1A4 was appreciably declined in the control group compared to that in the NC group and significantly increased in the L-AA and arbutin groups compared to that in the control group (P < .05) (Fig. 3G–J). The mRNA expression of COL1A1 was significantly increased in the IB complex 200 and IB complex 400 compared to that in the control group (74.8% and 153.3%, respectively) (P < .05) (Fig. 3G).

The mRNA expression of COL1A2 was significantly augmented in the IB complex 400 compared to that in the control group (122.4%), whereas the IB complex 100 and IB complex 200 were not significantly different (26.4% and 44.8%, respectively) (P < .05) (Fig. 3H). The mRNA expression of COL1A3 was significantly increased in the IB complex compared to that in the control group (61.0%–203.7%) (P < .05) (Fig. 3I). In addition, the mRNA expression of COL1A4 was significantly increased in the IB complex 200 and IB complex 400 compared to that in the control group (89.7% and 157.9%, respectively) (P < .05) (Fig. 3J).

DISCUSSION

In this study, IB complex increased mRNA expression of HAS1-3, LCB1 (SPT), DEGS1, and COL1A1-4 and protein expression of CerS4. Besides, the IB complex decreased protein expression of p-IκB/IκB and COX-2.

RESULTS

The mRNA expression of collagen synthesis-related factors such as COL1A1, COL1A2, COL3A1, and COL4A1 was appreciably declined in the control group compared to that in the NC group and significantly increased in the L-AA and arbutin groups compared to that in the control group (P < .05) (Fig. 3G–J). The mRNA expression of COL1A1 was significantly increased in the IB complex 200 and IB complex 400 compared to that in the control group (74.8% and 153.3%, respectively) (P < .05) (Fig. 3G).

The mRNA expression of COL1A2 was significantly augmented in the IB complex 400 compared to that in the control group (122.4%), whereas the IB complex 100 and IB complex 200 were not significantly different (26.4% and 44.8%, respectively) (P < .05) (Fig. 3H). The mRNA expression of COL3A1 was significantly increased in the IB complex compared to that in the control group (61.0%–203.7%) (P < .05) (Fig. 3I). In addition, the mRNA expression of COL4A1 was significantly increased in the IB complex 200 and IB complex 400 compared to that in the control group (89.7% and 157.9%, respectively) (P < .05) (Fig. 3J).

DISCUSSION

In this study, IB complex increased mRNA expression of HAS1-3, LCB1 (SPT), DEGS1, and COL1A1, COL1A2, COL3A1, COL4A1 and protein expression of CerS4. Besides, the IB complex decreased protein expression of p-IκB/IκB and COX-2.

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FIG. 3.

Effects of IB complex on mRNA expressions of HAS1 (A), HAS2 (B), HAS3 (C), fibrillin-1 (D), LCB1(SPT) (E), DEGS1 (F), COL1A1 (G), COL1A2 (H), COL1A3 (I), and COL1A4 (J) in the dorsal skin of UVB-irradiated SKH-I hairless mice. NC, AIN93G without UVB exposure; C, AIN93G with UVB exposure; L-AA, AIN93G supplemented 100 mg/kg body weight (BW) of L-ascorbic acid with UVB exposure; arbutin, AIN93G supplemented 100 mg/kg BW of arbutin with UVB exposure; IB complex 100, AIN93G supplemented 100 mg/kg BW of IB complex with UVB exposure; IB complex 200, AIN93G supplemented 200 mg/kg BW of IB complex with UVB exposure; IB complex 400, AIN93G supplemented 400 mg/kg BW of IB complex with UVB exposure. Data are presented as means±SD. Different letters (A–F) represent significant differences at P < 0.05, as determined by Duncan’s multiple range test.

OPEN IN VIEWER

FIG. 3.

Effects of IB complex on mRNA expressions of HAS1 (A), HAS2 (B), HAS3 (C), fibrillin-1 (D), LCB1(SPT) (E), DEGS1 (F), COL1A1 (G), COL1A2 (H), COL3A1 (I), and COL4A1 (J) in the dorsal skin of UVB-irradiated SKH-I hairless mice. NC, AIN93G without UVB exposure; C, AIN93G with UVB exposure; L-AA, AIN93G supplemented 100 mg/kg body weight (BW) of L-ascorbic acid with UVB exposure; arbutin, AIN93G supplemented 100 mg/kg BW of arbutin with UVB exposure; IB complex 100, AIN93G supplemented 100 mg/kg BW of IB complex with UVB exposure; IB complex 200, AIN93G supplemented 200 mg/kg BW of IB complex with UVB exposure; IB complex 400, AIN93G supplemented 400 mg/kg BW of IB complex with UVB exposure. Data are presented as means±SD. Different letters (A–F) represent significant differences at P < 0.05, as determined by Duncan’s multiple range test.