Availability of 0.3% Ofloxacin Ointment and Solution in Human Conjunctiva and Aqueous Humor

ABSTRACT

Ofloxacin 0.3% ophthalmic solution or ointment was administered preoperatively to 13 patients undergoing cataract surgery. Mean drug concentrations in conjunctival biopsies were 2.62 and 6.55 μg/gm and in aqueous humor samples were 0.36 μg/mL and 0.43 μg/mL, for ointment and solution respectively. Mean conjunctival concentrations of ofloxacin achieved MIC₉₀ values for 419 gram-positive and gram-negative organisms previously analyzed.