Abstract
Background:
Postpartum depression is prevalent among women who have had a baby within the last 12 months. Depression can compromise parenting practices, child development, and family stability. Effective treatments are available, but access to mental healthcare is challenging. Routine infant healthcare visits represent the most regular contact mothers have with the healthcare system, making pediatric primary care (PPC) an ideal venue for managing postpartum depression.
Methods:
We conducted a review of the published literature on postpartum depression programs. This was augmented with a Google search of major organizations' websites to identify relevant programs. Programs were included if they focused on clinical care practices, for at-risk or depressed women during the first year postpartum, which were delivered within the primary care setting.
Results:
We found that 18 programs focused on depression care for mothers of infants; 12 were developed for PPC. All programs used a screening tool. Psychosocial risk assessments were commonly used to guide care strategies, which included brief counseling, motivating help seeking, engaging social supports, and facilitating referrals. Available outcome data suggest the importance of addressing postpartum depression within primary care and providing staff training and support. The evidence is strongest in family practices and community-based health settings. More outcome data are needed in pediatric practices.
Conclusion:
Postpartum depression can be managed within PPC. Psychosocial strategies can be integrated as part of anticipatory guidance. Critical supports for primary care clinicians, especially in pediatric practices, are needed to improve access to timely nonstigmatizing care.
Introduction
P
Fortunately, maternal depression is identifiable and treatable. Benefits for children have been documented in treatment studies conducted outside of primary care. 7,13 Effective treatments for depression include a range of low- to high-intensity psychological interventions and pharmacological treatments. 14 However, healthcare utilization patterns suggest under-recognition and detection, 15 –17 especially among poor women of color. 18,19 Barriers to mental health treatment among these women are numerous and include myths about depression, time constraints, stigma, child care issues, and fears of provider judgment and social service involvement. 18,20 –22 The controversy around the safety of antidepressant medication use while breastfeeding influences the acceptability and comfort with medication by both women and their providers. 23 –25 These barriers, combined with health providers' reluctance to respond to maternal social–emotional and practical needs, are major obstacles in effectively linking these women to treatment. 18
Primary care is an ideal setting for the identification and management of depression in mothers, particularly postpartum depression. Recommendations exist for screening and management of depression in primary care. 26 Healthcare Effectiveness Data and Information Set (HEDIS) contains antidepressant medication management quality measures, and the American College of Obstetricians and Gynecologists (ACOG) and the American Psychiatric Association 27 have established guidelines for treatment of depression among perinatal women. Because maternal depression is a risk factor for child development, the American Academy of Pediatrics has also called for the incorporation of detection and management of maternal depression in pediatric practices. 28 However, few studies of depression management in primary care have focused on depression in mothers of infants. 29,30
Most women of childbearing age (84%) visit their own primary care physician once yearly. 31,32 Four of five women (but only 63% of women on Medicaid) receive a postpartum visit 4–6 weeks after delivery. 33,34 However, the health providers most accessed by women with infants are pediatric primary care (PPC) clinicians. Within the first 15 months of life, 78.2% of children (and 63.6% of children in Medicaid) received six or more well-child visits. 34,35 Thus, well-baby visits represent the most consistent contact mothers of infants have with the healthcare system. 36,37
Several efforts to implement universal depression screening of mothers of newborns have had mixed results. 38,39 Importantly, large-scale screening efforts that are not connected to follow-up do not influence treatment access or maternal outcomes. 40,41 Screening is recommended only when staff-assisted supports are in place. 2,26 To better understand factors that contribute to the success and/or failure of screening efforts, Yawn et al. undertook a review of postpartum depression screening programs. 39 They identified eight programs with outcome data; these programs were delivered in a variety of settings and varied in scope. Of these, only four programs included procedures for addressing women with elevated screening scores. Most reported process outcomes related to screening, diagnosis, and treatment referral or initiation rates. Only two of four studies with outcome data found a positive benefit. 42,43 Both of these programs included postscreening follow-up and management and treatment components within primary care. The review also found significant variation in physician or practice training and support.
To improve the identification and treatment of maternal depression, various initiatives have been implemented through national and state legislation. 41,44 Efforts have included programs for managing postpartum depression (typically defined as depression onset within 12 months of childbirth) as part of primary care. 39,43,45 –47 Because of the frequency of pediatric visits during the first year of a child's life, an opportunity exists within PPC settings not only to identify but also to monitor and manage postpartum depression symptoms. 48,49 Providing depression care within primary care settings is highly desirable to women, as it circumvents many attitudinal and practical barriers faced by mothers. This is especially the case when the venue is one in which routine care also occurs for their babies. 50
The goal of this article is to delineate key elements of maternal depression management conducted within primary care settings, with a focus on the first year postpartum, a period when women tend to have frequent contact with primary care via their children. To better understand how key practice elements from these various programs for postpartum depression management could be integrated into PPC settings, we built upon the review by Yawn et al. 39 Specifically, we systematically delineated practice elements within primary care settings. Unlike Yawn et al., we only focused on programs that delivered specific follow-up procedures for women with elevated depression screening scores within the primary healthcare context. We also included programs regardless of available outcome data because there were very few structured research studies. Policy initiatives related to this topic have spawned demonstration projects that could augment our understanding of practice elements potentially feasible in primary healthcare, outside of a research context. In addition, we examined whether the practice elements differed by context (e.g., adult vs. pediatric settings) and whether the context of their delivery influenced maternal or child outcomes. We focused on key aspects of these programs that might increase the success of identification and management of postpartum depression in primary care settings that provide routine well-child visits to highlight feasible approaches to the persistent problem of underidentification of maternal depression.
Materials and Methods
Two approaches were taken to identify relevant screening and management programs in primary care. The first was a review of the published literature on postpartum depression programs in primary care settings (pediatrics, family medicine, obstetrics–gynecology, community health centers). Second, we augmented our literature review with a Google search, with a focus on websites of major professional and caregiving/support organizations to identify relevant toolkits or programs related to the identification and treatment of postpartum or maternal depression. Secondary searches were also conducted by cross-referencing information or studies cited in key depression care programs.
Literature review: We conducted a comprehensive computerized search of the MEDLINE database on the Ovid platform (Ovid SP; Ovid Technologies, Inc., Philadelphia, PA) between February 10 and February 26, 2015. The search strategy for MEDLINE combined concepts “Maternal Depression,” “Postpartum,” and “Postnatal” with “Intervention,” “Screening,” “Risk Assessment,” or “Management.” From these concepts, we selected the relevant medical index subject headings (MeSH terms: mother–child relationships, expecting mothers, and depressive disorder). Inclusion criteria were as follows: peer-reviewed articles written in English with a focus on clinical care practices for women identified as at-risk for or depressed during the first postpartum year. Programs were excluded if they (1) focused on at-risk or depressed mothers whose children were outside of 0–1 years of age or had special needs (e.g., infants in the NICU and infants with HIV), (2) provided care that occurred outside the primary healthcare context (e.g., early intervention programs, home visiting programs, and psychiatric settings), or (3) provided no specific follow-up care to individuals who screened positive for depression. We chose to exclude screening-only programs because screening without follow-up is considered controversial and unethical. 14,26,38 In total, 1091 unique records were identified (Fig. 1). All search results were recorded in a reference management program (Endnote X7; Thomson Reuters, Carlsbad, CA). After reviewing these abstracts, we determined that 45 articles met criteria for a full text review. After full text review, nine articles (including one that was pulled based on cross-references 42 ) met criteria for final inclusion; these nine articles described nine unique programs (Fig. 1).

Postpartum depression care programs search flow chart.
Web-based search: The websites examined included the American Academy of Family Physicians, American Academy of Pediatrics, American Congress of Obstetricians and Gynecologists, Agency for Healthcare Research and Quality, American Medical Association, American Psychological Association, American Psychiatric Association, Centers for Disease Control and Prevention, National Academy for State Health Policy, National Institute of Mental Health, U.S. Preventive Services Task Force, and Substance Abuse and Mental Health Services Administration. Specific postpartum or maternal depression support websites included Clinicians Enhancing Child Health Practice-Based Research Network, Health Team Works, Illinois Academy of Family Physicians/Family Practice Education Network, and Postpartum Support International. In total, nine relevant toolkits or guidelines for identifying and managing postpartum depression were identified.
Abstraction of care features: In total, 18 programs were included in our review (Fig. 1); 9 from the literature review and 9 from web-based searches. Four of these 18 were initially selected for independent review by the study team to identify key elements of depression care. A final consensus set of features of postpartum depression care was then used to code all 18 programs. Features of care programs were organized according to key domains: screening/identification, assessment, care management, organization/system level tools that promote depression management, and the availability of outcome data. Using this code list, features of each care model were independently abstracted by two coders (D.W. and E.D.W.). Additional articles were pulled as needed by cross-referencing related publications to facilitate abstraction of program care features. Any discrepancies in coding were resolved by having the lead author review, and consensus was reached through team discussion.
Results
The 18 programs focused on depression care for mothers of infants are organized into two tables; the 9 programs from the literature review are asterisked. Table 1 includes 12 programs or toolkits that were developed for primary care settings where routine pediatric care is provided (i.e., pediatrics, n = 6 [one study also included family practice sites]; family medicine, n = 2; health centers, n = 4). All programs in pediatric practices and family medicine were based in the United States; all four programs in community-based health settings were internationally based. Table 2 includes six programs or toolkits that were developed for obstetrics and gynecology (ob-gyn) or generic toolkits developed for managing women with postpartum depression. All but one program 51 in Table 2 are U.S. based. Below, we present the common elements of these programs.
Identified from literature search.
EPDS, Edinburgh Postnatal Depression Scale; PHQ, Patient Health Questionnaire; RCT, randomized control trial; X, presence of practice element.
Identified from literature search.
X, presence of practice element.
Screening for depressive symptoms
All programs utilized a screening tool to facilitate identification of women with high levels of depressive symptoms (Tables 1 and 2). Several screening tools were used or endorsed; however, the Edinburgh Postnatal Depression Scale (EPDS) was the most common (found in 75% in PPC; 100% in ob-gyn and generic toolkits). Cut points used to identify those at risk for depression varied, with a score of 10 being the most commonly used. Significant variation existed in periodicity of screening, with screenings commonly recommended at 2 weeks through 6 months postpartum. In PPC settings, screenings at 4–6 weeks are most frequently seen (Table 1); in ob-gyn settings, 2 weeks are relatively more common.
Assessment
Suicide risks are examined as part of the most common screening tools (e.g., both EPDS and the Patient Health Questionnaire contain suicide items). Approximately half the programs identified specific crisis protocols for handling suicidality, 43,52 –58 with an emphasis in some for providers to be observant about the presence of rare but serious indicators of psychotic symptoms and thoughts of infant harm. 43,52
Only 5 of the 18 programs (28%) followed positive screens with a diagnostic confirmation. Three programs within PPC (Table 1) followed a positive screen with a structured psychiatric interview 54,59 or an additional tool to confirm diagnosis. 39 Two other programs recommended referral to a mental health provider for diagnostic confirmation before treatment. 56,60
In PPC settings, 75% of the programs included a psychosocial risk assessment, typically done through an interview (Table 1); two-thirds of adult primary care and generic toolkits also conducted or recommend risk assessments as part of postpartum depression care management (Table 2). Although risk assessment is typically done through an interview, a standardized risk assessment tool was specifically used in one program. 51 Ongoing monitoring of treatment adherence was uncommon in PPC settings, where only three programs monitored treatment adherence as part of care. 43,54,59 By contrast, all three ob-gyn settings monitored the treatment adherence of women who had positive screens. 51,52,56 Only two programs in PPC conducted child-level assessments. None of the programs in adult primary care or the generic toolkits recommended child assessment.
Care management of elevated postpartum depressive symptoms
Few of the 18 programs (17%) used or recommended use of a dedicated care manager to manage women with elevated depression symptoms. Care strategies commonly used can be broadly divided into “screen and refer” versus “screen and manage” approaches, with one toolkit, 60 suggesting use of either strategy based on practice capacity.
Few PPC programs used a “screen and refer” only approach. Rather, a “screen and manage” approach was more common, which included interventions such as counseling (typically nondirective or about lifestyle choices), psychoeducation about postpartum depression, motivating help seeking, engaging social supports, and referral to outside services as needed. None of the interventions involved psychotherapy; medication management was found in two family medicine-based programs 43,60 and one health center. 59 By contrast, ob-gyn or other settings were equally likely to use either a “screen and refer” or “screen and manage” approach. Management approaches included education, medication, motivating help-seeking outside practice, and engaging social supports.
Implementation supports at organizational/practice level
Implementation supports typically included training provided about postpartum depression as part of the initial program startup. However, ongoing organizational-level/practice-level support to implement postpartum depression screening and management was highly variable. Mental health consultation was available only in one-third of PPC-based programs and in two of the three ob-gyn settings. Referral networks were the most common strategy to support primary care practitioners across all settings (83% in PPC and 67% in other settings), followed by staffing guidelines (58% in PPC and 50% in other settings). Reimbursement strategies were relatively uncommon, especially in PPC.
Outcome data
Across the 18 programs, only 6 (all within PPC settings and all randomized control trials [RCTs]) reported outcome data, with only one extending beyond maternal health to child health. 42 Four of these six studies showed health benefits to the mother, with improved mental health outcomes for the mother posttreatment, 61 at 3 months, 59 6 months, 42 or 12 months. 43 However, effects diminished over time in two studies. 42,59 Reduction in postpartum depression was reported at 12 months in the largest family practice-based effectiveness trial conducted in the United States to date. These benefits were found with relatively modest nursing support focused on medication adherence and side effects. 43 Findings were negative in both studies that examined secondary outcomes related to parenting stress, partner satisfaction, or infant health. 42,43 In a three-arm RCT study based in Australia, women in the general practitioner-only condition were more likely to remain above the clinical cutoff for depression when compared to those who received adjunctive Cognitive Behavioral Therapy (CBT)-based counseling provided by a postnatal nurse or counseling provided by a psychologist. This finding supports the added benefit of adjunctive CBT-based counseling.
We compared the two negative studies with those that found positive outcomes to better understand contextual factors that may influence the outcomes of the two negative studies. The first negative study, called the PRISM study, 62 used a cluster-randomized design to test the effectiveness of a complex and multifaceted primary care and community-based strategy to facilitate the identification and support of new mothers across an Australian state. Compared to control women, those in the intervention arm did not show improvement in physical health scores or reduction in depression 6 months postbirth. In this program, maternal and child health nurses were not integrated with primary care services. Other potential barriers included reimbursement mechanisms based on a fee for service system, role diffusion of health nurses due to role shifts, and the lack of ongoing support for general practitioners and community building. In the second negative study based in both U.S. pediatric and family practices, a stepped care intervention increased women's awareness of their depression and their likelihood of getting treatment; however, no benefit was found for duration of treatment, health, or work outcomes. 54 A major limitation in the program design of this study was the requirement for a diagnostic confirmation by a mental health specialist for study enrollment. This introduced a significant bias, because fewer than a third of mothers who screened positive followed up with positive diagnostic assessments.
By contrast, the four studies that found benefits for maternal health included specific follow-up procedures that were all based within the primary care site. In these studies, less than 10% of the women who screened positive were referred for treatment outside the primary care practices. Key implementation supports were in place, including extensive and often tailored staff training and decision support tools to guide depression management. Ongoing mental health consultation was available to support management at three of these sites. 42,59,61
Discussion
Maternal depression is a public health issue because of the negative consequences on the mother, her child, and her family. Despite numerous efforts, linking new mothers to specialty mental health for depression treatment is challenging because of attitudinal, logistic, and structural barriers. These barriers are amplified among socially disadvantaged women, putting those most vulnerable at highest risk for unmet treatment needs and adverse long-term outcomes.
This review identified 18 unique programs or toolkits for managing postpartum depression within primary care. Care strategies were highly similar across both pediatric and adult settings. Two-thirds of the programs reviewed were based in settings that provided routine care for infants. This finding supports the notion that PPC is ideally suited for managing postpartum depression. Data are strongest for programs within family practices and community-based health settings. In particular, two large-scale multistate initiatives focused on family practice networks have been fielded within the United States, 43 with available data showing positive benefits on maternal health. 43 However, the majority of young children in the United States are seen by pediatricians. To date, the only rigorous U.S. study involving pediatric practices was compromised because the sample was biased by the requirement of a research-based diagnostic tool for study randomization 54 ; all other programs have involved demonstration projects with no outcome data. Thus, while the evidence suggests the feasibility of managing postpartum depression within pediatric practices, outcome data are needed. Unlike family practices and health centers that are set up to serve both children and adults, incentive structures and organizational supports must be established to support postpartum depression management programs in pediatric practices. 28,53
Among the primary care programs reviewed, a “screen and manage” approach was common, where depression in mothers was addressed to varying degrees within the practice where screening occurred. Interestingly, very few programs followed a positive screen with a confirmatory diagnostic interview. Psychosocial assessments, usually conducted via interview, were more commonly used as a basis to determine follow-up care strategies. Psychosocial risk assessments are considered both an opportunity to contextualize depressive symptoms within current life circumstances and to develop a successful management plan. 51,63,64 Thus, despite USPSTF recommendations to follow positive screens with confirmatory diagnosis, this is not typical in the programs we reviewed. In fact, requiring a diagnosis as a precursor to care provision was a deterrent for many women. 39,54 Few women with positive depression screens in primary care settings followed up with outside referrals, especially for diagnostic assessments. 27,39,54 Although it can be important to differentiate a positive screen from a depression diagnosis for individuals with complex mental health issues, the benefits of skipping this step may outweigh the risk of excluding women who endorse significant distress from the benefits of an intervention, especially among less clinically complex populations typically present in primary care. 39 A preventive approach, through which women with elevated symptoms and less complicated risk profiles could receive care, especially brief evidence-based interventions, is an important option. For women with more complex clinical profiles, coordination and/or linkages to specialty care are warranted.
Our review showed that various aspects of care were provided by a range of professionals, including the physician, nurses, midwives, or care managers. The primary care physician's role was most often to identify presence and degree of depression and to support the execution of a management plan through collaboration with allied health professionals and mental health specialists. Management within primary care typically involved brief counseling, motivating help seeking, engaging social supports, and facilitating mental health referrals. Few of these programs provided treatments; when treatment was provided, they involved primarily medication management. Available systems or organizational tools were typically in place to support depression care. Aside from initial training, development of referral networks is the most common type of organizational/practice support. Onsite or ongoing mental health consultation and decision support tools were less common though important strategies that were used in the programs with positive outcome data. 39,42,59,61 Incentives or reimbursement strategies were surprisingly rarely addressed, despite being identified as a major barrier for implementing such programs, especially in pediatric practice settings where mothers are not the identified patients.
Psychosocial interventions have been shown to be effective for adult depression, including those targeting postpartum depression. 65 –68 Despite the openness of mothers to nonpharmacological management of their depression within primary care, 69,70 programs relied primarily on nondirective counseling. It is likely that the implementation of these psychosocial interventions hinges on the availability of both trained providers and reimbursement mechanisms. Increasingly, evidence exists for the delivery of psychosocial interventions by lay and nonspecialty providers. 61,71 –74 With training and support, such strategies could potentially be adapted for delivery within PPC settings by allied health professionals, nurses, and physicians. 75 The availability of psychosocial interventions within primary care is particularly important for depressed women of infants, who understandably have concerns about antidepressant use, especially while nursing. Making brief psychosocial intervention options available within primary care could increase access to timely nonstigmatizing care for at-risk women and reduce the potential negative consequences for their child and family.
Efficacy trials support the benefits of integrating behavioral healthcare for depression within primary care 29 , however, challenges and variability in implementing such collaborative care models persist. 76,77 Stepped care approaches, a variant of collaborative care, have been proposed to increase the likelihood of care access for depressed mothers within PPC, where different levels of care are administered based on case severity. By moving from low to high levels of care, encouraging providers to manage low-level mental health needs and referring those with complex needs, efficiency and cost-effectiveness could be maximized. 39,54,78 A stepped care model, with comprehensive, one-stop early intervention services, has the advantage of addressing two key barriers, namely, limited availability of specialty mental health services and women's challenges with the logistics and attitudes about mental healthcare. However, outcome data for such models within pediatric practice settings are needed.
The emphasis on quality in the Affordable Care Act (ACA) creates an opportunity to focus attention on new models to optimize care for managing postpartum depression in PPC settings. While family practitioners have led the way in addressing this public health problem, pediatricians, who provide the majority of routine care for young children in the United States, have lagged behind. Because postpartum depression is a maternal condition, pediatricians are additionally challenged by legal, ethical, and reimbursement issues. 79 Barriers related to pediatricians' attitudes about managing depression in the mothers of their young patients and a lack of efficacy in identification and management of postpartum depression must also be addressed. 79 –84
Building on the National Quality Forum's recommendation to screen for maternal depression, models that expand upon existing strategies found in this review are important. In particular, supporting pediatric providers through targeted training, collaboration, and/or integration of behavioral health providers is key. Care models that emphasize a responsive, patient-centered, and evidence-based strategy for addressing this highly treatable maternal condition can promote health and long-term well-being of mothers and their children.
Footnotes
Acknowledgments
The authors thank Stephen Maher, MSIS, Assistant Director, Content Management and Scholarly Communications at the NYU Health Sciences Library. This research was supported by NIMH P30 MH09 0322.
Author Disclosure Statement
No competing financial interests exist.
