Abstract
In this issue of Therapeutic Hypothermia and Temperature Management, two expert panel discussions and original articles are presented that will be of interest to the readership of the Journal. One expert panel discussion focuses on perspectives on temperature management targeting three different complex biological mechanisms associated with clinical situations. Dr. Peter Andrews from Edinburgh, Scotland, moderated this interesting roundtable discussion. Dr. Shahed Toossi from Los Angeles, California, reported on cerebral autoregulation-oriented therapy after cardiac arrest and the effects of targeted temperature management. Dr. Michael Kurz from Birmingham, Alabama, presented information on peri-arrest coagulation and potential effects of temperature management on these outcome measures. Finally, Dr. Travis Jackson from Pittsburgh, Pennsylvania, provided preclinical and clinical evidence for the role of cold-adaptive neuroprotectant proteins in the brain. Another roundtable discussion featured three outstanding talks on therapeutic hypothermia in postcardiac arrest. Dr. Kees Polderman from London-Essex, United Kingdom, moderated this discussion. Dr. Justin Lundbye from Waterbury, Connecticut, gave a thorough review of therapeutic hypothermia from the historical perspective. This was followed by Dr. Graham Nichol from Seattle, Washington, who reported the findings of a meta-analysis of endovascular temperature management versus surface cooling. Finally, Dr. Michel Le May from Ottawa, Canada, provided an update on moderate hypothermia in the CAPITALCHILL study.
In addition to these expert panel discussions, original articles are also included in this issue. Dr. Assis and colleagues provide new information on the efficacy and safety of a novel noninvasive transnasal evaporative cooling device (CoolStat) in a large animal model. Dr. Jiang and colleagues studied the food storing hibernator chipmunk and its degree of tolerance to global cerebral ischemia during deep hypothermic cerebral circulatory arrest. The consequences of intra-arrest hypothermia through large-volume ice-cold saline in New York City were presented by Dr. Freese and colleagues. Another article on cardiac arrest in piglets by Dr. Yuan and colleagues studied the effects of mild hypothermia on organ protection after ischemia reperfusion. Dr. Verius and colleagues review their results on using a 3T proton magnetic resonance spectroscopy thermometry for human brain temperature estimation for routine clinical applications. A retrospective cohort study at a single trauma center by Dr. Cragun and colleagues reported on the safety of therapeutic hypothermia in trauma and surgical patients. Finally, Dr. Arnaez and colleagues describe a case study of a newborn infant with spinal cord injury treated with whole body cooling and erythropoietin due to complications presented during instrumental delivery.
This issue also includes our Arctic Challenge section that provides a number of question-and-answer sections highly relevant to the field of therapeutic hypothermia and targeted temperature management. The readership of the Journal will benefit from these thoughtful discussions, questions, and current literature citations. We thank the authors for their important contributions as well as the editorial board for their critical support in reviewing these informative articles in a timely manner.