Abstract
US 7700825 Granted patent Published 20 Apr 2010
Recombinant Constructs and Transgenic Fluorescent Ornamental Fish Therefrom
Inventors/Applicants
The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green, and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and to provide to the ornamental fish industry for the purpose of marketing. Thus, new varieties of ornamental fish of different fluorescence colors from a novel source are developed.
US 7700347 Granted patent Published 20 Apr 2010
Methods and Apparatuses for Conducting Assays in Animals
Applicants/Inventors
The invention provides apparatuses, systems, and methods for conducting assays in aquatic animals. These apparatuses, systems, and methods can be used to identify and/or characterize compounds that modulate morphological, anatomical, or behavioral characteristics and learning or memory.
US 2010/0088773 A1 Patent application Published 8 Apr 2010
Mutations in Lama2 Gene of Zebrafish
Inventors/Applicants
This invention relates to isolated nucleic acid molecules encoding mutant lama2 gene of zebrafish, mutant zebrafish having mutations in the lama2 gene, fish models containing mutant zebrafish, and uses of the fish models.
US 7687682 Granted patent Published 30 Mar 2010
Methods of Screening Agents for Activity Using Teleosts
Inventors/Applicants
This invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity, and cell death activity in teleosts are provided. This invention further provides high-throughput methods of screening agents in multiwell plates.
US 7671251 Granted patent Published 2 Mar 2010
In Vivo Assay for Neurite Outgrowth in Zebrafish and Its Application in Drug Screening
Inventors/Applicants
A genetically modified zebrafish embryo comprising a heparin-binding neurotrophic factor (HBNF) cDNA, a nerve growth factor (NGF) cDNA, or a glial-derived neurotrophic factor (GDNF) cDNA together with a cDNA encoding green fluorescent protein so as to induce neurite outgrowth during zebrafish embryonic development, and a method of using such a genetically modified zebrafish embryo to identify a therapeutic agent are disclosed.
US 2010/0047246 A1 Patent application Published 25 Feb 2010
Methods and Compositions for Treating Vascular Disease
Inventors/Applicants
This invention relates to compositions and methods for use in treating or preventing vascular disease, as well as diseases and conditions associated with hematopoiesis and cellular proliferation.
US 2010/0037330 A1 Patent application Published 11 Feb 2010
Efficient Somatic Cell Nuclear Transfer in Fish
Inventors/Applicants
This invention provides methods of producing enucleated cells by photoablation. Such enucleated cells may be used as recipient cells for somatic cell nuclear transfer and cloning. The nuclear donor and/or enucleated recipient cells may be any fish cells, such as zebrafish, koi, or medaka fish cells. Such methods may be used to efficiently produce transgenic fish by using, for examples, zebrafish, koi, and medaka fish.
Footnotes
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