Abstract
US 2010/0313820 A1 Patent application Published 16 Dec 2010
Systems and Methods for the Portable Electroanesthesia of Fish
Applicants/Inventors
A portable fish-anesthetizing system is also described having a tank cover, an electrode pair that is configurable and attached to the tank cover, and a control system for creating a potential difference. The control system electrically connected to the electrode pair, so that when the tank cover is placed on a laboratory tank and the control system is activated, current flows from the control system through the electrodes.
US 2010/0310574 A1 Patent application Published 9 Dec 2010
Methods and Compositions for the Treatment and Diagnosis of Statin-Induced Myopathy
Applicants/Inventors
The invention provides compositions and kits containing an atrogin-1 inhibitor compound useful for the treatment of a statin-mediated myopathy. Kits for the diagnosis of a statin-mediated myopathy are also provided. The invention further features methods for treating or preventing a statin-mediated myopathy in a subject via administration of a therapeutically effective amount of an atrogin-1 inhibitor compound. The invention further provides methods of diagnosing a subject as having a propensity to develop a statin-induced myopathy and methods of monitoring a statin-induced myopathy or a propensity to develop a statin-mediated myopathy in a subject. The invention also features methods for identifying a compound for the treatment of a statin-mediated myopathy and methods of identifying a statin compound as having the propensity to induce a statin-mediated myopathy.
US 2010/0297684 A1 Patent application Published 25 Nov 2010
Activatible Dyes
Applicants/Inventors
Novel, activatable dyes, such as photoactivatable dyes, for example, oxazine dyes, are described. Some of the dyes are targeting dyes that can, for example, target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.
US 7834239 Granted patent Published 16 Nov 2010
Sale of Transgenic Fish That Express Gene Encoding Fluorescent Protein
Applicants/Inventors
Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific, and ubiquitously expressed, respectively, were isolated and ligated to the 5′ end of the EGFP gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used. Thus, new varieties of ornamental fish of different fluorescence patterns, for example, skin fluorescence, muscle fluorescence, skeletal muscle-specific, and/or ubiquitous fluorescence, are developed.
US 2010/0287627 A1 Patent application Published 11 Nov 2010
Transgenic Zebrafish Models for Neurodegenerative Diseases
Applicant/Inventor
The present invention relates to zebrafish models for neurodegenerative disorders, which allow screening of compounds for their ability to protect and/or regenerate neurons in vivo in a whole vertebrate organism. The present invention also provides methods of identifying gene targets for neuroprotective compounds, which regenerate neurons and promote neurogenesis.
US 2010/0286044 A1 Patent application Published 11 Nov 2010
Detection of Tissue Origin of Cancer
Applicants/Inventors
Disclosed is a method for determining the cellular or tissue origin of tumor cells. The method entails determining the presence of at least one micro-RNA (miRNA) in a sample derived from tumor tissue and, based on the said determination, establishing an miRNA expression profile and comparing this with preestablished miRNA expression profiles from cells, tissues, or tumors. The determination uses short oligonucleotide probes comprising modified affinity-enhancing nucleobases.
US 2010/0266675 A1 Patent application Published 21 Oct 2010
Lipoproteins, Lipopeptides, and Analogs and Methods for Making and Using Them
Applicants/Inventors
This invention provides novel compositions—lipopeptides and analogs, including somocystinamide A and its variants and analogs; pharmaceutical compositions, comprising of liposomes and nanoparticles; and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell, and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating), and/or tumor-associated blood vessels, including endothelial and/or capillary cell growth including neovasculature related to (within, providing a blood supply to) a tumor.
Footnotes
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