Microbiological Interaction and Diffusion Properties of Hydrophilic and Hydrophobic PU Membranes

Abstract

In this study, the diffusion characteristics of Diclofenac-Na through hydrophobic and hydrophilic polyurethane (PU) based membranes areinvestigated. Hydrophilic polymers are obtained via graft copolymerization of PU with acrylic acid (AA) and crotonic acid (CA). The membranes are prepared by solvent-casting method and characterized by FTIR spectra and SEM analysis. The diffusion measurements are performed using a diffusion cell during 10 h at 37 °C. Permeability coefficients calculated from diffusion experiments are found to be approximately three times higher in hydrophilic membrane than hydrophobic PU membrane. The adherence of Escherichia coli (E. coli) and Staphylococcusaureus (S. aureus) onto the membranes at 37 °C were also investigated. It is determined that the microorganisms didn’t adhere onto the membranes compared by control suspension.

Keywords

polyurethane acrylic acid crotonic acid itaconic acid acrylamide diclofenac-Na membrane adherence diffusion permeability coefficient SEM E. coli S. aureus

Get full access to this article

View all access options for this article.

References

1. Edwars, C. , Cope, A.S. , Jackson, A.H. and Purkiss, R. (1983). J. Clin. Hosp. Pharm., 8: 63-63.

2. Robinson, J.R. (1979). Sustained and Controlled Release Drug Delivery Systems. New York: Dekker.

3. Paul, D.R. and Harris, F.W. (1976). Controlled Release Polymeric Formulations. ACS Symp. Ser. Washington, DC: American Chemical Society.

4. Lager, R. (1983). Drug Ther., 4: 217-217.

5. Langer, R. and Peppas, N.A. (1981). Biomaterials, 2: 195-195.

6. Jenne, L.W. , Wyze, E. , Rood, E.S. and MacDonald, M. (1972). Clin. Pharmacol. Ther., 13: 349-349.

7. Lelah, M.D. and Cooper, S.L. (1986). Polyurethane in Medicine. Boca Raton, FL: CRC.

8. Bruck, S.D. (1973). J. Biomed. Mater. Res., 7: 387-387.

9. Ito, Y. (1989). Biocompatibility. CRC Crit. Rev., 5: 45-45.

10.

10. Wisman, C.B. , Pierce, W.S. , Donachy, J.H. and Pae, W.E. (1984). Trans. Am. Soc. Artif. Intern. Organs., 28: 113-113.

11.

11. Touitou, E. and Friedman, D. (1984). Int. J. Pharm., 19: 323-323.

12.

12. Egboh, S.H. , George, M.H. , Barrie, J.A. and Walsh, D.J. (1983). Makromol. Chem., 184: 725-725.

13.

13. Jansen, B. and Ellinghorst, G. (1979). J. Polym. Sci., Polym. Symp., 66: 465-465.

14.

14. Egboh, S.H. , George, M.H. and Barrie, J.A. (1984). Polymer, 25: 1157-1157.

15.

15. Abidi, K. , George, M.H. and Barrie, J.A. (1979). Polymer, 20: 483-483.

16.

16. Pedram, M.Y. , Vega, H. and Quijada, R. (1996). Macromol. Rapid. Commun., 17: 577-577.

17.

17. Pulat, M. and Babayiğit, D. (2001). Polymer Testing, 20(2): 209-209.

18.

18. Pulat, M. and Babayiğit, D. (2001). J. Appl. Polym. Sci., 80: 2690-2690.

19.

19. Ho, H. , Liu, C.H. , Lin, H.M. and Sheu, M.T. (1997). J. Cont. Release, 49: 149-149.

20.

20. Wilder, P.V. , Detaevernier, M.R. and Michotte, Y. (1991). Drug Development and Industrial Pharmacy, 17: 141-141.

21.

21. Kiremitçi, M. , Pulat, M. , Şenvar, C. , Serbetçi, A. and Piskin, E. (1990). Clin. Mater., 6: 227-227.

22.

22. Kiremitçi, M. , Peşmen, A. , Pulat, M. and Gürhan, İ (1993). J. Biomat. Appl., 7: 250-250.

23.

23. Abbasoğlu, U. and Pulat, M. (1994). FABAD J. Pharm. Sci., 19: 1-1.

24.

24. Pulat, M. (1994). Reactive and Functional Polymers, 24: 59-59.

25.

25. Pulat, M. and Şenvar, C. (1995). Polymer Testing, 14: 115-115.

26.

26. Pulat, M. and Abbasoğlu, U. (1995). J. Biomat. Appl., 9: 363-363.

27.

27. Robb, E.C. , Fitz, D.G. and Nathan, P. (1980). Trans. Am. Soc. Artif. Intern. Organs, 26: 533-533.

28.

28. Sheu, M.T. , Chou, H.L. , Kao, C. , Liu, C.H. and Sokoloski, T. (1992). Int. J. Pharm., 85: 57-57.

29.

29. Trotta, M. , Gasco, M.R. and Morel, S. (1989). J. Cont. Release., 10: 237-237.

30.

30. Kydonieus, A.F. (1980). Controlled Release Technologies: Methods, Theory and Applications, V 1. Florida: CRC Press Inc.

31.

31. Behar, D. , Juszynski, M. , Ben Hur, N. , Golan, J. , Eldad, E. , Tuchman, Y. , Sterenberg, N. and Rudensky, B. (1986). J. Biomed. Mat. Res., 20: 731-731.

32.

32. Hirabayashi, Y. , Satoh, H. , Ogawa, H. and Ohtsuka, Y. (1983). J. Appl. Polym. Sci., 28: 109-109.

33.

33. Pulat, M. and Akdoğan, A. (2002). J. Appl. Polym. Sci., (in press).

34.

34. USP XVIII, Microbiological Tests, (1970). Easton, Washington D.C: Mack print. Comp. 845–855.

35.

35. Williams, D.H. and Fleming, I. (1973). Spectroscopies Methods in Organic Chemistry. GB: Mc Graw Hill.

36.

36. Todd, P.A. and Sorkin, E.M. (1988). Diclofenac Sodium, Drugs. 35: 244-244. Auckland: ADIS Press Limited.