WeberGF. Why does cancer therapy lack effective anti-metastasis drugs?Cancer Lett2013;328:207–11.doi:10.1016/j.canlet.2012.09.025http://www.ncbi.nlm.nih.gov/pubmed/23059758
2.
TalmadgeJE, FidlerIJ. Aacr centennial series: the biology of cancer metastasis: historical perspective. Cancer Res2010;70:5649–69.doi:10.1158/0008-5472.CAN-10-1040http://www.ncbi.nlm.nih.gov/pubmed/20610625
MontanariM, RossettiS, CavaliereC, . Epithelial-Mesenchymal transition in prostate cancer: an overview. Oncotarget2017;8:35376–89.doi:10.18632/oncotarget.15686http://www.ncbi.nlm.nih.gov/pubmed/28430640
6.
LoU-G, LeeC-F, LeeM-S, . The role and mechanism of epithelial-to-mesenchymal transition in prostate cancer progression. Int J Mol Sci2017;18. doi:doi:10.3390/ijms18102079. [Epub ahead of print: 30 Sep 2017].http://www.ncbi.nlm.nih.gov/pubmed/28973968
7.
AlizadehJ, ShojaeiS, SepanjniaA, . Simultaneous detection of autophagy and epithelial to mesenchymal transition in the non-small cell lung cancer cells. Methods Mol Biol2019;1854:87–103.doi:10.1007/7651_2017_84http://www.ncbi.nlm.nih.gov/pubmed/29101677
8.
AlizadehJ, GlogowskaA, ThliverisJ, . Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells. Biochim Biophys Acta Mol Cell Res2018;1865:749–68.doi:10.1016/j.bbamcr.2018.02.007http://www.ncbi.nlm.nih.gov/pubmed/29481833
9.
EshraghiM, AdlimoghaddamA, MahmoodzadehA, . Alzheimer's disease pathogenesis: role of autophagy and mitophagy focusing in microglia. Int J Mol Sci2021;22:3330. doi:10.3390/ijms22073330http://www.ncbi.nlm.nih.gov/pubmed/33805142
10.
ShojaeiS, SureshM, KlionskyDJ, . Autophagy and SARS-CoV-2 infection: Apossible smart targeting of the autophagy pathway. Virulence2020;11:805–10.doi:10.1080/21505594.2020.1780088http://www.ncbi.nlm.nih.gov/pubmed/32567972
11.
ShojaeiS, KoleiniN, SamieiE, . Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes. Febs J2020;287:1005–34.doi:10.1111/febs.15069http://www.ncbi.nlm.nih.gov/pubmed/31545550
12.
YangA, RajeshkumarNV, WangX, . Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov2014;4:905–13.doi:10.1158/2159-8290.CD-14-0362http://www.ncbi.nlm.nih.gov/pubmed/24875860
13.
RaoS, TortolaL, PerlotT, . A dual role for autophagy in a murine model of lung cancer. Nat Commun2014;5:3056. doi:10.1038/ncomms4056http://www.ncbi.nlm.nih.gov/pubmed/24445999
14.
BaoY, DingZ, ZhaoP, . Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-β/Smad3 signaling in melanoma cells. Cell Death Dis2020;11:223.doi:10.1038/s41419-020-2419-yhttp://www.ncbi.nlm.nih.gov/pubmed/32265437
15.
DingY-H, ZhouZ-W, HaC-F, . Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells. Drug Des Devel Ther2015;9:425–64.doi:10.2147/DDDT.S74062http://www.ncbi.nlm.nih.gov/pubmed/25624750
16.
WangF, LiH, YanX-G, . Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. Drug Des Devel Ther2015;9:575–601.doi:10.2147/DDDT.S75221http://www.ncbi.nlm.nih.gov/pubmed/25632225
17.
Karimi RoshanM, SoltaniA, SoleimaniA, . Role of Akt and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process. Biochimie2019;165:229–34.doi:10.1016/j.biochi.2019.08.003http://www.ncbi.nlm.nih.gov/pubmed/31401189
18.
GuoR, MengQ, GuoH, . TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway. Mol Med Rep2016;13:1105–10.doi:10.3892/mmr.2015.4645http://www.ncbi.nlm.nih.gov/pubmed/26647778
19.
LuQ, WangW-W, ZhangM-Z, . Ros induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Ther Med2019;17:835–46.doi:10.3892/etm.2018.7014http://www.ncbi.nlm.nih.gov/pubmed/30651870
20.
PiresBRB, MencalhaAL, FerreiraGM, . Nf-kappaB is involved in the regulation of EMT genes in breast cancer cells. PLoS One2017;12:e0169622. doi:10.1371/journal.pone.0169622http://www.ncbi.nlm.nih.gov/pubmed/28107418
21.
ChenL-M, SongT-J, XiaoJ-H, . Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/Akt/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells. Oncotarget2017;8:63911–22.doi:10.18632/oncotarget.19201http://www.ncbi.nlm.nih.gov/pubmed/28969040
22.
LinM-C, LeeY-W, TsengY-Y, . Honokiol induces autophagic apoptosis in neuroblastoma cells through a p53-dependent pathway. Am J Chin Med2019;47:895–912.doi:10.1142/S0192415X19500472http://www.ncbi.nlm.nih.gov/pubmed/31091975
23.
LinC-J, ChenT-L, TsengY-Y, . Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway. Toxicol Appl Pharmacol2016;304:59–69.doi:10.1016/j.taap.2016.05.018http://www.ncbi.nlm.nih.gov/pubmed/27236003
24.
BabaeiG, AzizSG-G, JaghiNZZ. Emt, cancer stem cells and autophagy; the three main axes of metastasis. Biomed Pharmacother2021;133:110909.doi:10.1016/j.biopha.2020.110909http://www.ncbi.nlm.nih.gov/pubmed/33227701
25.
ZhuH, WangD, ZhangL, . Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia. Oncol Rep2014;32:935–42.doi:10.3892/or.2014.3298http://www.ncbi.nlm.nih.gov/pubmed/24994549
26.
MrakovcicM, FröhlichLF. P53-Mediated molecular control of autophagy in tumor cells. Biomolecules2018;8:14. doi:10.3390/biom8020014http://www.ncbi.nlm.nih.gov/pubmed/29561758
27.
RenD, WangM, GuoW, . Wild-Type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145. Int J Oncol2013;42:1473–81.doi:10.3892/ijo.2013.1825http://www.ncbi.nlm.nih.gov/pubmed/23404342