About 70 per cent of patients with hepatocellular carcinoma are diagnosed at intermediate or advanced stages, and most of them are technically unresectable. As a novel, emerging therapeutic modality, high intensity focused ultrasound (HIFU) has a great potential for tumor treatment. In this review, principle of HIFU technique is introduced, and an overview of clinical applications and limitations of HIFU for HCC treatment, as well as prospects for future development, is provided. Consequently, HIFU has been considered a safe and feasible procedure for HCC treatment.
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References
1.
ThomasM.B., ZhuA.X.Hepatocellular carcinoma: the need for progress.J Clin Oncol2005; 23: 2892–9.
MakuuchiM., KosugeT., TakayamaT.Surgery for small liver cancers.Semin Surg Oncol1993; 9: 298–304.
4.
LiY.Y., ShaW.H., ZhouY.J.Short and long term efficacy of high intensity focused ultrasound therapy for advanced hepatocellular carcinoma.J Gastroenterol Hepatol2007; 22: 2148–54.
5.
DaleckiD.Mechanical bioeffects of ultrasound.Annu Rev Biomed Eng2004; 6: 229–48.
6.
LeslieT.A., KennedyJ.E.High-intensity focused ultrasound principles, current uses, and potential for the future.Ultrasound Q2006; 22: 263–72.
7.
ter HaarG.R.Therapeutic application of ultrasound.Prog Biophys Mol Biol2007; 93: 111–29.
8.
LiJ.J., XuG., LuoG.Y.Complications of high intensity focused ultrasound for primary liver cancer.Chin J Ultrasonog2006; 9: 668–70.
9.
XueJ., ShaW.H., NieY.Q.Efficacy of high intensity focused ultrasound in treatment of hepatocellular carcinoma and its influential factors.World J Gastroenterol2006; 14: 3377–81.
10.
YoungS.K., HyunchulR., MinJ.C.High-intensity focused ultrasound therapy: an overview for radiologists.Korean J Radiol2008; 9: 291–302.
11.
WuF., WangZ.B., ChenW.Z.Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview.Ultrason Sonochem2004; 11: 149–54.
12.
WuF., ChenW.Z., BaiJ.Effect of high-intensity focused ultrasound on the patients with hepatocellular carcinoma: preliminary report.Chin J Ultrasonogr1999; 8: 213–6.
13.
WuF., WangZ.B., ChenW.Z.Extracorporeal high intensity focused ultrasound in the treatment of patients with large hepatocellular carcinoma.Ann Surg Oncol2004; 11: 1061–9.
14.
ZhangL., ZhuH., JinC.High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins.Eur J Radiol2009; 19: 437–45.
15.
ZhuH., ZhouK., ZhangL.High-intensity focused ultrasound (HIFU) therapy for local treatment of hepatocellular carcinoma: role of partial rib resection.Eur J Radiol2009; 72: 160–6.
16.
OrsiF., ZhangL., ArnoneP.High-intensity focused ultrasound ablation: effective and safe therapy for solid tumors in difficult locations.AJR Am J Roentgenol2010; 195: 245–52.
17.
KazushiN., HiroyukiF., MasaoO.Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation of hepatocellular carcinoma by three-dimensional sonography with a perflubutane-based contrast agent.Eur J Radiol2010; 75: e67–75.
18.
NgK.K., PoonR.T., ChanS.C.High-intensity focused ultrasound for hepatocellular carcinoma: a single-center experience.Ann Surg2011; 253: 981–7.
19.
WuF., WangZ.B., ChenW.Z.Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization.Radiology2005; 235: 659–67.
20.
ZhangL., FanW.J., HuangJ.H.Comprehensive sequential interventional therapy for hepatocellular carcinoma.Chin Med J (Engl)2009; 122: 2292–8.
21.
DoddG.D.III, SoulenM.C., KaneR.A.Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough.Radiographics2000; 20: 9–27.
22.
LiC., ZhangW., ZhangR.Therapeutic effects and prognostic factors in high-intensity focused ultrasound combined with chemoembolisation for larger hepatocellular carcinoma.Eur J Cancer2010; 46: 2513–21.
23.
JinC.B., ZhuH., WangZ.B.High-intensity focused ultrasound combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: long-term follow-up and clinical analysis.Eur J Radiol2010; Epub ahead of print.
24.
LiC.X., WuP.H., FanW.J.Clinical effect of transcatheter arterial chemoembolization combined with high intensity focused ultrasound ablation in treatment of large hepatocellular carcinoma.Zhonghua Yi Xue Za Zhi2009; 89: 754–7.
25.
TachibanaK., TachibanaS.The use of ultrasound for drug delivery.Echocardiography2001; 18: 323–8.
26.
LiuY., YangH., SakanishiA.Ultrasound: mechanical gene transfer into plant cells by sonoporation.Biotechnol Adv2006; 24: 1–16.
27.
MillerD.L., PislaruS.V., GreenleafJ.E.Sonoporation: mechanical DNA delivery by ultrasonic cavitation.Somat Cell Mol Genet2002; 27: 115–34.
28.
StewartE.A., RabinoviciJ., TempanyC.M.Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids.Fertil Steril2006; 85: 22–9.
29.
LiJ.J., XuG.L., GuM.F.Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors.World J Gastroenterol2007; 13: 2747–51.
30.
FurusawaH., NambaK., ThomsenS.Magnetic resonance-guided focused ultrasound surgery of breast cancer: reliability and effectiveness.J Am Coll Surg2006; 203: 54–63.
31.
LencioniR., ChenX.P., DagherL.Treatment of intermediate/advanced hepatocellular carcinoma in the clinic: how can outcomes be improved?Oncologist2010; 15(suppl 4): 42–52.
32.
IkedaK., KumadaH., SaitohS.Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma.Cancer1991; 68: 2150–4.
