We assessed the association between serum heat shock protein 27 (Hsp-27)concentrations in patients with acute coronary syndrome (ACS) and compared them with healthy participants. Patients with ACS (n = 75) were recruited and their biochemical parameters were compared with 75 healthy participants. Heat shock protein 27 concentrations were measured from blood samples taken on admission and 12 hours after the onset of chest pain. In the patient group, Hsp-27 concentrations (31.62 [20.12-38.51] ng/mL) in the first blood samples were significantly (P < .001) higher than in control samples (20.12 [16.67-28.17] ng/mL). In patients, serum Hsp-27 levels on admission were significantly (P < .001) higher than for the samples collected 12 hours after the onset of chest pain (25.87 [15.52-31.62]); the latter did not differ significantly from samples of healthy controls. In conclusion, serum Hsp-27 concentrations are elevated in the early hours following ACS, but fall to levels near to those in healthy individuals after about 12 hours from the onset of chest pain.
BraunwaldE. Shattuck lecture—cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med. 1997;337(19):1360–1369.
2.
FernsGA. New and emerging risk factors for CVD. Proc Nutr Soc. 2008;67(2):223–231.
3.
GarridoCGurbuxaniSRavagnanLKroemerG. Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun. 2001;286(3):433–442.
4.
JaattelaMWissingDKokholmKKallunkiTEgebladM. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 1998;17(21):6124–6134.
5.
KirchhoffSRGuptaSKnowltonAA. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002;105(24):2899–2904.
6.
WickGSchettGAmbergerAKleindienstRXuQ. Is atherosclerosis an immunologically mediated disease?. Immunol Today. 1995;16(1):27–33.
7.
Ghayour-MobarhanMRahseparAATavallaieSRahseparSFernsGA. The potential role of heat shock proteins in cardiovascular disease: evidence from in vitro and in vivo studies. Adv Clin Chem. 2009;48:27–72.
8.
BrueyJMPaulCFromentinA. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene. 2000;19(42):4855–4863.
9.
KabakovAEBudagovaKRBryantsevALLatchmanDS. Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis. Cell Stress Chaperones. 2003;8(4):335–347.
10.
ChretienPLandryJ. Enhanced constitutive expression of the 27-kDa heat shock proteins in heat-resistant variants from Chinese hamster cells. J Cell Physiol. 1988;137(1):157–166.
11.
Martin-VenturaJLDuranMCBlanco-ColioLM. Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis. Circulation. 2004;110(15):2216–2219.
12.
ParkHKParkECBaeSW. Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome. Circulation. 2006;114(9):886–893.
13.
ShamsSShafiSBodman-SmithK. Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clin Chim Acta. 2008;395(1-2):42–46.
14.
Ghayour-MobarhanMSahebkarAParizadehSM. Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome. Int J Exp Pathol. 2008;89(3):209–215.
15.
CreaFGaspardoneATomaiF. Risk factors in schoolchildren associated with a family history of unheralded myocardial infarction or uncomplicated stable angina in male relatives. J Am Coll Cardiol. 1994;23(6):1472–1478.
16.
YambolievIAHedgesJCMutnickJLAdamLPGerthofferWT. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol. 2000;278(6):H1899–H1907.
17.
Vander HeideRS. Increased expression of HSP27 protects canine myocytes from simulated ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2002;282(3):H935–H941.
18.
SchimkeILutschGSchernesU. Increased level of HSP27 but not of HSP72 in human heart allografts in relation to acute rejection. Transplantation. 2000;70(12):1694–1697.
19.
GruberRLedererSBechtelULobSRiethmüllerGFeuchtHE. Increased antibody titers against mycobacterial heat-shock protein 65 in patients with vasculitis and arteriosclerosis. Int Arch Allergy Immunol. 1996;110(1):95–98.
20.
BirnieDHHolmeERMcKayICHoodSMcCollKEHillisWS. Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J. 1998;19(3):387–394.
21.
XuQKiechlSMayrM. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation. 1999;100(11):1169–1174.
22.
DybdahlBSlordahlSAWaageAKierulfPEspevikTSundanA. Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction. Heart. 2005;91(3):299–304.
23.
MoohebatiMFalsoleimanHDehghaniM. Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention. Angiology. 2011;62(2):184–190.
24.
MukherjeeMDeBCJewittDKakkarVV. Association of antibodies to heat-shock protein-65 with percutaneous transluminal coronary angioplasty and subsequent restenosis. Thromb Haemost. 1996;75(2):258–260.
25.
SchettGMetzlerBKleindienstR. Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response. Cardiovasc Res. 1999;42(3):685–695.
26.
ShamsSShafiSBodman-SmithKWilliamsPMehtaSFernsGA. Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clin Chim Acta. 2008;395(1-2):42–46.
