We sought to determine whether serial measurements of oxidative stress levels could serve as a predictive marker for cardiovascular (CV) events in patients with ST-segment elevation myocardial infarction (STEMI). Biological antioxidant potential (BAP) levels were measured at admission and at 6, 12, and 24 months in 69 patients with STEMI. The CV events abruptly increased 6 to 10 months after successful percutaneous coronary intervention in patients with STEMI, and the 6-month BAP levels were significantly lower in patients with CV events (2456 μmol/L [interquartile range: 2237-2615 μmol/L]) than in those without (2849 μmol/L [2575-2987 μmol/L], P < .001). A decreased 6-month BAP level was an independent and significant predictor of long-term CV events (hazard ratio = 2.45; 95% confidence intervals 1.10-5.78; P = .04). Our findings suggest that serial changes in antioxidant capacity, assessed by BAP levels, may serve as a predictive marker for CV events after STEMI.
O’GaraPTKushnerFGAscheimDD. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary. A report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation2013;127(4):529–555.
2.
StegPGJamesSKAtarD. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Task force on the management of ST-segment elevation acute myocardial infarction of the European society of cardiology (ESC). Eur Heart J. 2012;33(20):2569–2619.
FörstermannU. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med. 2008;5(5):338–349.
5.
SinghUJialalI. Oxidative stress and atherosclerosis. Pathophysiology. 2006;13(3):129–142.
6.
McCordJM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312(3):159–163.
7.
KochiadakisGEArfanakisDAMarketouME. Oxidative stress changes after stent implantation: a randomized comparative study of sirolimus-eluting and bare metal stents. Int J Cardiol. 2010;142(1):33–37.
8.
JuniRPDuckersHJVanhouttePMVirmaniRMoensAL. Oxidative stress and pathological changes after coronary artery interventions. J Am Coll Cardiol. 2013;61(14):1471–1481.
9.
SundaresanMYuZXFerransVJIraniKFinkelT. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995;270(5234):296–299.
10.
GriendlingKKFitzGeraldGA. Oxidative stress and cardiovascular injury: part II: animal and human studies. Circulation. 2003;108(17):2034–2040.
11.
van BeusekomHMWhelanDMHofmaSH. Long-term endothelial dysfunction is more pronounced after stenting than after balloon angioplasty in porcine coronary arteries. J Am Coll Cardiol. 1998;32(4):1109–1117.
12.
AmorosoGvan VeldhuisenDJTioRAMarianiM. Pathophysiology of vascular endothelium and circulating platelets: implications for coronary revascularization and treatment. Int J Cardiol. 2001;79(2-3):265–275.
13.
OhtaniKEgashiraKIharaY. Angiotensin II type 1 receptor blockade attenuates in-stent restenosis by inhibiting inflammation and progenitor cells. Hypertension. 2006;48(4):664–670.
14.
KashimaYIzawaAAizawaK. Rationale and design of assessmentof lipophilic vs. hydrophilic statin therapy in acute myocardial infarction (the ALPS-AMI) study. J Cardiol. 2009;54(1):76–79.
15.
CavalleriAColomboCVenturelliE. Evaluation of reactive oxygen metabolites in frozen serum samples. Effect of storage and repeated thawing. Int J Biol Markers. 2004;19(3):250–253.
16.
KakitaHHusseinMHDaoudGA. Total hydroperoxide and biological antioxidant potentials in a neonatal sepsis model. Pediatr Res. 2006;60(6):675–679.
17.
VassalleCBianchiSBattagliaDLandiPBianchiFCarpeggianiC. Elevated levels of oxidative stress as a prognostic predictor of major adverse cardiovascular events in patients with coronary artery disease. J Atheroscler Thromb. 2012;19(8):712–717.
18.
VassalleCBianchiSBianchiFLandiPBattagliaDCarpeggianiC. Oxidative stress as a predictor of cardiovascular events in coronary artery disease patients. Clin Chem Lab Med. 2012;50(8):1463–1468.
19.
StrobelNAFassettRGMarshSACoombesJS. Oxidative stress biomarkers as predictors of cardiovascular disease. Int J Cardiol. 2011;147(2):191–201.
20.
GrewePHDenekeTMachraouiABarmeyerJMüllerKM. Acute and chronic tissue response to coronary stent implantation: pathologic findings in human specimen. J Am Coll Cardiol. 2000;35(1):157–163.
21.
FarbABurkeAPKolodgieFDVirmaniR. Pathological mechanisms of fatal late coronary stent thrombosis in humans. Circulation. 2003;108(14):1701–1706.
22.
CannonCPBraunwaldEMcCabeCH. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350(15):1495–1504.
