Time Course and the Recanalization Rate of Superficial Vein Thrombosis Treated With Low-Molecular-Weight Heparin

Abstract

The aim of this study was to follow the thrombus progression and regression in superficial veins of lower limbs in patients with superficial vein thrombosis (SVT) treated with low-molecular-weight heparin. Patients (n = 68) with a first symptomatic SVT of the lower limbs received 2 different dosages of dalteparin. The primary outcome was a change in the diameter and length of thrombus in the affected veins. The regression of thrombus was not significantly different between the groups (P = .19). The reduction in the length of thrombus as well as thrombus diameter was significantly greater in females. At the end of the observation period, the length of thrombus in the distal part was more reduced than in the proximal segments. It seems that the dosage of anticoagulant drug does not have a significant impact on thrombus resolution.

Keywords

recanalization thrombosis superficial veins ultrasound heparin

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References

Karathanos

Sfyroeras

Drakou

. Superficial vein thrombosis in patients with varicose veins: role of thrombophilia factors, age and body mass. Eur J Vasc Endovasc Surg. 2012;43(3):355–358.

Hill

Hancock

Webb

. Thrombophlebitis of the great saphenous vein—recommendations for treatment. Phlebology. 2008;23(1):35–39.

Decousus

Quéré

Presles

. Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med. 2010;152(4):218–224.

Jorgensen

Hanel

Morgan

Hunt

. The incidence of deep venous thrombosis in patients with superficial thrombophlebitis of the lower limbs. J Vasc Surg. 1993;18(1):70–73.

Di Nisio

Wichers

Middeldorp

. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev. 2012;3:CD004982.

Karathanos

Exarchou

Tsezou

Kyriakou

Wittens

Giannoukas

. Factors associated with the development of superficial vein thrombosis in patients with varicose veins. Thromb Res. 2013;132(1):47–50.

Kalodiki

Stvrtinova

Allegra

. Superficial vein thrombosis: a consensus statement. Int Angiol. 2012;31(3):203–216.

Prandoni

Tormene

Pesavento

, Group VI. High vs. low doses of low-molecular-weight heparin for the treatment of superficial vein thrombosis of the legs: a double-blind, randomized trial. J Thromb Haemost. 2005;3(6):1152–1157.

Kearon

Akl

Comerota

. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141:e419S–e494S.

10.

Kitchens

. How I treat superficial venous thrombosis. Blood. 2011;117(1):39–44.

11.

Nicolaides

Hull

Fareed

. Key questions to be answered. Clin Appl Thromb Hemost. 2013;19(2):224–225.

12.

Jezovnik

Poredos

. Factors influencing the recanalisation rate of deep venous thrombosis. Int Angiol. 2012;31(2):169–175.

13.

Kockx

Knaapen

Bortier

Cromheeke

Boutherin-Falson

Finet

. Vascular remodeling in varicose veins. Angiology. 1998;49(11):871–877.

14.

Sevitt

. The mechanisms of canalisation in deep vein thrombosis. J Pathol. 1973;110(2):153–165.

15.

Puskás

Balogh

Hadadi

. Spontaneous recanalization in deep venous thrombosis: a prospective duplex ultrasound study. Int Angiol. 2007;26(1):53–63.

16.

Decousus

Prandoni

Mismetti

. Fondaparinux for the treatment of superficial-vein thrombosis in the legs. N Engl J Med. 2010;363(13):1222–1232.

17.

Poredos

Jezovnik

. Dyslipidemia, statins, and venous thromboembolism. Semin Thromb Hemost 2011;37(8):897–902.

18.

Paraskevas

Nicolaides

Mikhailidis

. Statins and venous thromboembolism: the jury is still out. Angiology. 2013;64(7):489–491.

19.

Kostapanos

Florentin

Elisaf

Mikhailidis

. Hemostatic factors and the metabolic syndrome. Curr Vasc Pharmacol. 2013;11(6):880–905.

20.

Prandoni

Casiglia

Tikhonoff

Leizorovicz

Decousus

Investigators

. The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs. Blood. 2011;118(17):4719–4722.