Postprocedural Skin Perfusion Pressure Correlates With Clinical Outcomes 1 Year After Endovascular Therapy for Patients With Critical Limb Ischemia

Abstract

Background:

Although skin perfusion pressure (SPP) is widely used clinically to predict probability of wound healing, correlation between clinical outcomes and SPP has not been systematically studied.

Methods:

This subanalysis of the prospective multicenter OLIVE registry of patients who received infrainguinal endovascular therapy (EVT) for critical limb ischemia (CLI) assessed the association between clinical outcomes and postoperative SPP in 211 consecutive patients. Logistic regression analysis was performed, with amputation-free survival (AFS), modified major adverse limb events (MALEs), and complete wound healing as dependent variables and postprocedural SPP as independent variable.

Result:

Pre- and postprocedural SPP was 28 ± 11 and 46 ± 18 mm Hg, respectively. In logistic regression analysis, postprocedural SPP correlated with 1-year AFS (P = .018), modified MALEs (P < .001), and wound healing (P = .022).

Conclusion:

Postprocedural SPP correlates with clinical outcomes after EVT for patients with CLI.

Keywords

skin perfusion pressure critical limb ischemia the endovascular treatment for infrainguinal vessel (OLIVE) Registry

Get full access to this article

View all access options for this article.

References

Yamada

Ohta

Ishibashi

. Clinical reliability and utility of skin perfusion pressure measurement in ischemic limbs—comparison with other noninvasive diagnostic methods. J Vasc Surg. 2008;47(2):318–323.

Takkin

Richard

Patrick

Philip

. Prediction of wound healing outcome using skin perfusion pressure and transcutaneous oximetry: a single-center experience in 100 patients. Wounds. 2009;21(11):310–316.

Adera

James

Castronuovo

Byrne

Deshmukh

Lohr

. Prediction of amputation wound healing with skin perfusion pressure. J Vasc Surg. 1995;21(5):823–829.

Castronuovo

Adera

Smiell

Price

. Skin perfusion pressure measurement is valuable in the diagnosis of critical limb ischemia. J Vasc Surg. 1997;26(4):629–637.

Iida

Nakamura

Yamauchi

. Endovascular treatment for infrainguinal vessels in patients with critical limb ischemia: OLIVE registry, a prospective, multicenter study in Japan with 12-month follow-up. Circ Cardiovasc Interv. 2013;6(1):68–76.

Iida

Soga

Yamauchi

. Clinical efficacy of endovascular therapy for patients with critical limb ischemia attributable to pure isolated infrapopliteal lesions. J Vasc Surg. 2013;57(4):974–981.

Iida

Soga

Kawasaki

. Angiographic restenosis and its clinical impact after infrapopliteal angioplasty. Eur J Vasc Endovasc Surg. 2012;44(4):425–431.

Conte

Geraghty

Bradbury

. Suggested objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia. J Vasc Surg. 2009;50(6):1462–1473.