The prevalence of metabolic syndrome (MetS) has increased globally and is associated with an increased risk of cardiovascular diseases that may be related to its association with inflammation. We have assessed whether the prevalence of the MetS correlates with a serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of US men and women. Participants were selected from the US National Health and Nutrition Examination Survey from 2005 to 2010. Of the 17 689 participants analyzed, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample (between men and women P = .047). The prevalence of MetS, diabetes mellitus, and hypertension increased across quartiles for hsCRP (all P < .001). Moreover, we found that for the age-, race-, sex-, and smoking-adjusted logistic regression, with increasing hsCRP, the risk of having MetS increased with an odds ratio of 5.20 (95% confidence interval, 4.54-5.93, P < .001) when comparing the highest quartile of serum hsCRP with the lowest. This study provides further evidence for an association between MetS and subclinical inflammation.
ReavenGM. The insulin resistance syndrome: definition and dietary approaches to treatment. Ann Rev Nutr. 2005;25(7):391–406.
2.
EckelRHGrundySMZimmetPZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–1428.
3.
ErtekSBanachM. Editorial: the changing face of metabolic syndrome and its components in the light of current knowledge. Curr Vasc Pharmacol. 2014;12(4):549–552.
4.
Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–2497.
5.
FordES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care. 2005;28(11):2745–2749.
6.
MazidiMPennathurSAfshinniaF. Link of dietary patterns with metabolic syndrome: analysis of the National Health and Nutrition Examination Survey. Nutr Diabetes. 2017;7(3):e255.
7.
LakkaHMLaaksonenDELakkaTA. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709–2716.
8.
RizzoMBarylskiMRizviAAMontaltoGMikhailidisDPBanachM. Combined dyslipidemia: Should the focus be LDL cholesterol or atherogenic dyslipidemia?Curr Pharm Des. 2013;19(21):3858–3868.
9.
MazidiMGaoHKVatanparastHKengneAP. Impact of the dietary fatty acid intake on C-reactive protein levels in US adults. Medicine (Baltimore). 2017;96(7):e5736.
10.
MazidiMHeidari-BakavoliAKhayyatzadehSS. Serum hs-CRP varies with dietary cholesterol, but not dietary fatty acid intake in individuals free of any history of cardiovascular disease. Eur J Clin Nutr. 2016;70(12):1454–1457.
11.
MazidiMKengneAPP MikhailidisDF CiceroABanachM. Effects of selected dietary constituents on high-sensitivity C-reactive protein levels in U.S. adults. Ann Med. 2017. doi: 10.1080/07853890.2017.1325967
12.
MazidiMKarimiERezaiePFernsG. Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2016;31(7):1237–1242.
13.
DevarajSSinghUJialalI. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol. 2009;20(3):182–189.
14.
ZakiMEEl-BassyouniHTEl-GammalMKamalS. Indicators of the metabolic syndrome in obese adolescents. Arch Med Sci. 2015;11(1):92–98.
15.
MazidiMRezaiePFernsGAVatanparastH. Impact of probiotic administration on serum C-reactive protein concentrations: systematic review and meta-analysis of randomized control trials. Nutrients. 2017;9(1). pii: E20.
16.
MazidiMKengneAP. Nutrient patterns and their relationship with general and central obesity in US adults[Published online March 10, 2017]. Eur J Clin Invest. doi:10.1111/eci.12745
17.
MazidiMKengneAPBanachM. Mineral and vitamins consumption is associated with longer telomeres among US adults. Pol Arch Med Wewn. 2017;127(2):87–90.
18.
MazidiMKengneAPSahebkarABanachM. Telomere length is associated with cardiometabolic factors in US adults[Published online January 1, 2017]. Angiology. doi: 10.1177/0003319717712860
GrundySMBrewerHBJrCleemanJISmithSCJrLenfantC. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109(3):433–438.
21.
MazidiMMichosEDBanachM. The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: The National health and nutrition examination survey. Arch Med Sci. 2017;13(1):61–65.
RidkerPMWilsonPWGrundySM. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk?Circulation. 2004;109(23):2818–2825.
24.
RidkerPM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103(13):1813–1818.
25.
MazidiMKarimiERezaiePFernsGA. Effects of conjugated linoleic acid supplementation on serum C-reactive protein: a systematic review and meta-analysis of randomized controlled trials[Published online May 29, 2017]. Cardiovasc Ther. doi: 10.1111/1755-5922.12275
26.
HuffmanFGGomezGPZariniGG. Metabolic syndrome and high-sensitivity C-reactive protein in Cubans. Ethn Dis. 2009;19(2):115–120.
27.
KangESKimHJAhnCW. Relationship of serum high sensitivity C-reactive protein to metabolic syndrome and microvascular complications in type 2 diabetes. Diabetes Res Clin Pract. 2005;69(2):151–159.
28.
YudkinJSJuhan-VagueIHaweE. Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study. Metabolism. 2004;53(7):852–857.
29.
VoilsSACooper-DeHoffRM. Association between high sensitivity C-reactive protein and metabolic syndrome in subjects completing the National Health and Nutrition Examination Survey (NHANES) 2009-10. Diabetes Metab Syndr. 2014;8(2):88–90.
30.
VongpatanasinWThomasGDSchwartzR. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation. 2007;115(8):1020–1028.
31.
SzmitkoPEVermaS. C-reactive protein and reendothelialization: NO involvement. Circ Res. 2007;100(10):1405–1407.
32.
de GasparoMCattKJInagamiTWrightJWUngerT. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52(3):415–472.
33.
D’AlessandrisCLauroRPrestaISestiG. C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. Diabetologia. 2007;50(4):840–849.
34.
RidkerPMHennekensCHBuringJERifaiN. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342(12):836–843.
35.
FestaAD’AgostinoRJrHowardGMykkanenLTracyRPHaffnerSM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study (IRAS). Circulation. 2000;102(1):42–47.
36.
FestaAD’AgostinoRJrTracyRPHaffnerSM. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes. 2002;51(4):1131–1137.
