An Experimental Method for Quantitative Evaluation of Thrombolysis: Effect of Ca-7,a Protease from Aspergillus Oryzae

Henry, R.L. : Methods for inducing experimental thrombosis. Angiology, 13: 554, 1962.

Hume, M. , Glenn, W.W.L. , and Grillo, T. : Behavior in the circulation of the radioactive pulmonary embolus and its application to the study of fibrinolytic enzymes. Ann. Surg., 151: 507, 1960.

Ambrus, J.L. , Back, N. , Goldstein, S. , Ambrus, C.M. , and Harrison , J.W.E. : In vivo fibrinolytic effect of various proteolytic enzymes: quantitative tests employing iodine131-labeled clots. J. Am. Pharm. A. (Sc. Ed.), 48: 298, 1959.

Lewis, J.H. , Kerber, C.W. , and Wilson, J.H. : Effects of fibrinolytic agents and heparin on intravascular clot lysis. Am. J. Physiol., 207: 1044, 1964.

Johnson, A.J. and McCarty, W.R. : The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J. Clin. Invest., 38: 1627, 1959.

Grossi, C.E. , Cliffton, E.E. , and Cannemela, D.A. : Lysis of intravascular thrombi in rabbits with human plasmin (fibrinolysin) . Blood, 9: 310,1954.

Wessler, S. : Studies in intravascular coagulation. III. Pathogenesis of serum induced venous thrombosis. J. Clin. Invest., 34: 647, 1955.

Marin, H.M. , and Stefanini, M. : Experimental production of phlebothrombosis. Surg., Gynec. and Obst., 110: 263,1960.

Boyles, P.W. , and Meyer, W.H. : A quantitative method for the study of thrombolysis. Angiology , 15: 326, 1964.

Tosoni, A. L., and Ives, D. A. J.: Canadian Patent 671,648, Oct. 1 (1963) and U.S. Patent 3,140,984, July 14 (1964).

Tosoni, A. L., and Glass, D. G.: Canadian Patent 671,647, Oct. 1 (1963).

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. I. Methods for the estimation and isolation of the proteolytic enzymes. Acta chem. scandinav., 17: 1521, 1963.

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. II. Properties of the proteolytic enzymes. Acta chem. scandinav., 17: 1541, 1963.

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. III. A comparison of the fibrinolytic and fibrinogenolytic effects of the enzymes. Acta chem. scandinav, 17: 2230, 1963 .

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. IV. On the inhibition of the enzymes by serum. Acta chem. scandinav. 17: 2239, 1963.

Roschlau, W.H.E. : The evaluation in the dog of a proteolytic enzyme derived from Aspergillus oryzae. Canad. J. Physiol. & Pharmacol., 42: 109, 1964.

Bergkvist, R. , and Svärd, P.O. : Studies on the thrombolytic activity of a protease from Aspergillus oryzae. Acta physiol. scandinav. , 60: 363, 1964.

Dyer, A.E. , and Kadar, D. : Fibrin suspension assay for fibrinolytic activity. Blood, 23: 729, 1964.

Siegel, S. : Non Parametric Statistics, p. 116. McGraw-Hill Book Co., Inc., New York, 1956.