Collagen and elastin in the arterial wall are thought to show some age-dependent changes, and to relate with development of the arteriosclerotic lesion.
Both aortas and the pulmonary trunks were collected from 137 autopsy cases. Biochemical determination of collagen and elastin content was carried out. Collagen and elastin of the aorta and the pulmonary artery showed no significant age-dependent changes. Elastin content of the pulmonary artery increases with age in the adult.
This paper seems to be the first report of simultaneous estimation of collagen and elastin content of both the aorta and the pulmonary artery.
Get full access to this article
View all access options for this article.
References
1.
Hosoda Y., Minoshima I.: Elastin content of the aorta and the pulmonary artery in the Japanese . Angiology16: 325-332, 1965.
2.
Inayama S., et al: A new microanalytical method for determination of hydroxyproline in connective tissue. Keio J Med27: 43-46, 1978.
3.
Jackson DS, Cleary EG: The determination of collagen and elastin. Methods of BiochemAnalysis15:25-76, 1967.
4.
Myers VC, Lang WW: Some chemical changes in the human thoracic aorta accompanying the aging process . J Geront1:441-444, 1946.
5.
Faber M., Møller-Hou G.: The human aorta. V. Collagen and elastin in the normal and hypertensive aorta . Acta patho microbiol scand31: 377-382, 1952.
6.
Clausen B.: Influence of age on connective tissue. Hexosamine and hydroxyproline in human aorta, myocardium, and skin. Lab Invest11: 229-234, 1952.
7.
Smith EB: The influence of age and atherosclerosis on the chemistry of aortic intima . J Atheroscl Res5: 241-248, 1965.
8.
Kanabrocki E. , et al: Calcium, cholesterol, and collagen levels in human aortas. J Geront15: 383-387, 1960.
Farrar JP, et al: The structure and composition of the maturing pulmonary circulation . J Path Bact90: 83-96, 1965.
11.
MacKay EH, et al: Structural basis for the changing physical properties of human pulmonary vessels with age. Thorax33: 335-344, 1978.
12.
Lansing SI, et al: The significance of medial age changes in the human pulmonary artery. J Geront5: 211-215, 1950.
13.
Castillo Y. , et al: Histology, extensibility, and chemical composition of pulmonary trunk in persons living at sea-level and at high altitude in Peru. Brit Heart J29: 120-128, 1967.
14.
Plank L., et al: Caliber and elastin content of the pulmonary trunk. Arch Pathol Lab Med104: 238-241, 1980.
15.
Harris P., et al: Extensibility of the human pulmonary trunk. Brit Heart J27: 651-659, 1965.
