tcpO 2,Arterial Blood Flow and Lactate/Pyruvate Modifications Induced by a Single Dose of Naftidrofuryl IV During Stage III Lower-Limb Arteriopathies

Abstract

A single dose of 600 mg of naftidrofuryl perfused IV during three hours in 12 stage III arteriopathic patients did not modify the average blood flow at the calf but did significantly increase transcutaneous oxygen pressure (33 vs 52 mmHg) and also improved lactates (1.44 vs 0.88 mmol/liter), pyruvate (59 vs 79 μmol/liter), and lactates-pyruvates ratio (33.48 vs 20.92).

Get full access to this article

View all access options for this article.

References

Ehrly AM , Schroeder W. : Oxygen pressure values in the ischemic muscle tissue of patients with chronic arterial disease. In: Oxygen Transport to Tissue, ed. by Silver IA. New York, Plenum, 1978, pp. 401-405.

Gudbjarnason S. , Bing RJ : The index of the lactatepyruvate system in blood as an indicator of the functional state of cellular oxidation. Biochim Biophys Acta, 60:158-162, 1962.

Hlavova A. , Linhart J. , Prerovsky J. , et al: Lactate and pyruvate changes in the leg during and after exercise in normal subjects and in patients with femoral artery occlusion. Clin Sci 34:397-409, 1968.

Maas U. , Alexander K. : Lactate and pyruvate changes during treadmill exercise in patients with intermittent claudication. Z Kardiol 71:39-43, 1982.

Brugmans J. , Jaqueneau A. , Horig G. , et al: Modern technics in venous occlusion plethysmography in the assessment of peripheral vascular disease. Proc Royal Soc 70 (Suppl 8):1-6, 1977.

Pointel JP , Gin H. , Drouin P. , et al: Venous plethysmography measuring techniques and normal values . Angiology 32:145-154, 1981.

Borzykowski J. , Krähenbühl B. : Measurement of pedal transcutaneous oxygen tension to follow up lower limbs arterial occlusive disease. Vasa 10:137-142, 1980.

Elert C. , Niebel W. , Karuse E. , et al: The effect of Naftidrofuryl on energy metabolism in the musculature of limbs with impaired blood flow. Therapie Woche 26:3947-3950, 1976.

Archer AG , Robert VC , Watkins PJ : Blood flow patterns in painful diabetic neuropathy. Diabetologia 27:563-567, 1984.

10.

Gundersen Hjg : Peripheral blood flow and metabolic control in juvenile diabetes. Diabetologia 10:225-231, 1974.

11.

Pointel JP , Stoltz JF , Rousselle D. , et al: Peripheral arterial blood flow in insulin dependent diabetic patients. Influence of glycemia control and blood viscosity. In: Hemorheology and Diseases, ed. by Stoltz JF , Drouin P. Nancy , France, Doin 1979, pp. 277-284.

12.

Pointel JP , Rousselle D. , Ethgen D. , et al: Normalisation des débits artériels et des paramètres rhéologiques chez le diabétique sous l'effet de l'équilibre glycémique par pancréas artificiel . In: Hemodynamics of the Limbs 2, ed. by Puel P , Boccalon H , Enjalbert A , Toulouse, France, 1981, pp. 287-291.