Decreased Prevalence of Symptomatic Atherosclerosis in Arthritis Patients on Long-Term Aspirin Therapy

Abstract

To determine the effect of long-term aspirin therapy on the prevalence of symptomatic atherosclerosis, autopsy results from 44 arthritis patients taking aspirin were compared with a cohort from the general autopsy population. No decrease in the prevalence of symptomatic atherosclerosis was noted in patients with less than 8 years of arthritis, compared with controls. In contrast, the prevalence of symptomatic atherosclerosis was significantly decreased in arthritis patients with 8 or more years of arthritis and aspirin use. In these subjects, the prevalence of symptomatic atherosclerosis was inversely related to duration of arthritis. The inverse relationship between prevalence of symptomatic atherosclerosis and duration of aspirin therapy, as well as the decrease in all forms of symptomatic atherosclerosis, raise the possibility that this decrease is due to primary prevention of atherosclerosis.

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References

The Steering Committee of the Physicians' Health Study Research Group : Final report of the aspirin component of the ongoing physicians' health study N Engl J Med 321:129-134, 1989.

Peto R. , Gray R. , Collins R., et al : Randomized trial of prophylactic daily aspirin in British male doctors Br Med J 296:313-316, 1988.

Heath C. Jr : Rheumatoid arthritis, aspirin, and gastrointestinal cancer J Natl Cancer Inst 84:258-259, 1993.

Wolfe F. , Mitchell DM , Sibley JT, et al : The mortality of rheumatoid arthritis Arthritis Rheum 37:481-494, 1994.

Barnett RN : Clinical Laboratory Statistics Boston: Little, Brown, and Co, 1979, p 27.

Ford I. : Is blood donation good for the donor? Heart 78:107, 1997.

Ball J. : Postmortem findings and articular pathology in rheumatoid arthritis In: Rheumatic Diseases, ed. by Duthie JJR, Alexander WRM. Baltimore: The Williams and Wilkins Co, 1968, pp 123-126.

Gardner DL : Pathology of Rheumatoid Arthritis Baltimore: The Williams and Wilkins Co, 1972, p 213.

Bennett GA : Comparison of the pathology of rheumatic fever and rheumatoid arthritis Ann Intern Med 19:111-113, 1943.

10.

Willard JE , Lange RL , Hillis LD : The use of aspirin in ischemic heart disease N Engl J Med 327:175-181, 1992.

11.

Patrono P. : Aspirin as an antiplatelet drug N Engl J Med 330:1287-1294, 1994.

12.

Schoen FJ : Blood vessels In: Robbins Pathologic Basis of Disease , ed. by Cotran RS, Kumar V, Robbins SL. Philadelphia : WB Saunders Co, 1994, pp 473-483.

13.

Lakatos J. , Harsagyi A. : Serum total, HDL, LDL, cholesterol, and triglycerides in patients with rheumatoid arthritis Clin Biochem 21:93-96, 1988.

14.

Philbin EF , Groff GD , Ries MD, et al : Cardiovascular fitness and health in patients with end stage osteoarthritis Arthritis Rheum 38:799-805, 1995.