Sex Differences in Time Trends on Incidence Rates of Oropharyngeal and Oral Cavity Cancers in Hong Kong

Abstract

Objectives:

Worldwide studies have shown an increasing trend of oropharyngeal squamous cell carcinoma (OPSCC) but a decreasing trend of oral cavity cancers over the past 2 decades, particularly in developed countries with successful tobacco control. This trend has been attributed to the increase in the incidence of human papillomavirus (HPV)–associated OPSCC. The aim of this study was to examine sex differences in incidence trends of oropharyngeal and oral cavity cancers in Hong Kong from 1983 to 2014.

Methods:

Using data from the Hong Kong Cancer Registry from 1983 to 2014, age-standardized incidence rates for potentially HPV-associated sites (oropharyngeal) and non-HPV-associated sites (oral cavity) were calculated, stratified by sex and age groups. Joinpoint regression and an age-period-cohort model were used to assess incidence trends.

Results:

A total of 1,972 cases of oropharyngeal cancer and 7,389 cases of oral cavity cancer were diagnosed from 1983 to 2014. The male/female ratios were 4.16:1 for oropharyngeal cancers and 1.63:1 for oral cavity cancers. A significant increasing trend was observed in oropharyngeal cancers from 1994 to 2014 (average annual percentage change = 2.66, P < .05). In contrast, a significant decreasing trend was observed in oral cavity cancers from 1983 to 1994 (average annual percentage change = −5.36, P < .05). The trends were more significant in men and in patients aged 45 to 69 years. A positive birth cohort effect was observed for oropharyngeal cancer in men.

Conclusions:

The rising trend of oropharyngeal cancer and decreasing trend of oral cavity cancer in Hong Kong from 1983 to 2014 are consistent with worldwide trends. Increase in high-risk sexual behaviors and oral HPV infection may influence the difference in trends.

Keywords

cancer incidence head and neck cancer human papilloma virus HPV oral cancer oropharyngeal cancer

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References

Siegel

Miller

Jemal

. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7.

Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108.

International Agency on Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Betel-Quid and Areca-Nut Chewing and Some Areca-Nut Related Nitrosamines. Vol. 85. IARC; 2004.

Mehanna

Beech

Nicholson

et al . Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta-analysis of trends by time and region. Head Neck. 2013;35:747-755.

Simard

Torre

Jemal

. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol. 2014;50:387–403

Nguyen

Chi

Nguyen

Karlsson

Vinh-Hung

. Human papillomavirus-associated oropharyngeal cancer: a new clinical entity. Q J Med. 2010;103:229-236.

Chaturvedi

Engels

Anderson

Gillison

. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26:612-619.

McKaig

Baric

Olshan

. Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head Neck. 1998;20:250-265.

Pytynia

Dahlstrom

Sturgis

. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol. 2014;50:380-386.

10.

Chor

Vlantis

Chow

et al . The role of human papillomavirus in head and neck squamous cell carcinoma: a case control study on a southern Chinese population. J Med Virol. 2016;88(5):877-887.

11.

Lam

Chan

et al . Prevalence, clinicopathological characteristics, and outcome of human papillomavirus-associated oropharyngeal cancer in southern Chinese patients. Cancer Epidemiol Biomarkers Prev. 2016;25(1):165-173.

12.

Hsu

Shen

Y-C

Cheng

C-C

et al . Difference in the incidence trend of nasopharyngeal and oropharyngeal carcinomas in Taiwan: implication from age-period-cohort analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:856-861.

13.

Ushida

McGrath

ECM

Zwahlen

. Oral cavity cancer trends over the past 25 years in Hong Kong: a multidirectional statistical analysis. BMC Oral Health. 2015;15:83.

14.

World Health Organization, Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death. 2nd ed. Geneva, Switzerland: World Health Organization; 2004.

15.

Rosenberg

Check

Anderson

. A web tool for age-period-cohort analysis of cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev. 2014;23:2296-2302.

16.

Rutherford

Lambert

Thompson

. Age-period-cohort modeling. Stata J. 2010;10(4):606-627.

17.

Chi

. Oral cavity and oropharyngeal squamous cell carcinoma – an update. CA Cancer J Clin. 2015;65:401-421.

18.

Gooi

Chan

Fakhry

. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope. 2016;126:894-900.

19.

Schantz

. Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg. 2002;128:268-274.

20.

Howlader

Noone

Krapcho

et al , eds. SEER Cancer Statistics Review, 1975-2012. Bethesda, MD: National Cancer Institute; 2015.

21.

Forte

Niu

Lockwood

Bryant

. Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992-2009. Cancer Causes Control. 2012;23:1343-1348.

22.

Ariyawardana

Johnson

. Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982-2008: overall good news but with rising rates in the oropharynx. BMC Cancer. 2013;13:333.

23.

Choi

Moon

Park

et al . Trends in the incidence of and survival rates for oral cavity cancer in the Korean population. Oral Dis. 2014;20:773-779.

24.

Lam

Lim

W-Y

Chow

K-Y

D’Souza

. Incidence, trends and ethnic differences of oropharyngeal, anal and cervical cancers: Singapore, 1968-2012. PLoS ONE. 2015;10(12):e0146185.

25.

Smoking Prevalence and Population in Hong Kong, 1982-2012. Thermatic Survey Reports, HKSAR Census and Statistics Department. Available at: https://www.tco.gov.hk/textonly/tc_chi/infostation/infostation_sta_01.html.

26.

Alcohol Consumption per Capita in Hong Kong 2004-2015. Census and Statistics Department, HKSAR. Available at: http://www.change4health.gov.hk/en/alcohol_aware/figures/alcohol_consumption/index.html.

27.

Leung

Thach

Lam

et al . Trends in breast cancer incidence in Hong Kong between 1973 and 1999: an age-period-cohort analysis. Br J Cancer. 2002;87(9):982-988.

28.

Yip

Zhang

Lam

et al . Sex knowledge, attitudes, and high-risk sexual behaviors among unmarried youth in Hong Kong. BMC Public Health. 2013;13:691.

29.

FPAHK: The Youth Sexuality Study. Hong Kong: The Family Planning Association of Hong Kong; 2006. Available at: http://drive.famplan.org.hk/FPAHK/Research/YSS06.pdf.

30.

Report on the Assessment of Recently Acquired HIV Infection in Men Having Sex with Men (MSM) in Hong Kong. The Chinese University of Hong Kong, March 2007. Available at: http://www.info.gov.hk/aids/pdf/g189.pdf.

31.

Kreimer

Alberg

Daniel

et al . Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis. 2004;189:686-698.

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