In this paper the potential use of hematoporphyrin-derivative (HpD) phototherapy in the local treatment of bronchogenic carcinoma is discussed. Ten patients with cancer involving the tracheobronchial tree have completed at least one course of HpD-mediated laser phototherapy administered by means of the flexible fiberbronchoscope. Complete response was obtained in four cases, and in each case the tumor was small and superficial. Larger tumors with greater degrees of invasion showed only a partial response. Two patients with tumors eroding through the bronchial wall died following treatment. It appears that HpD phototherapy may be useful for control of only small, superficial squamous cell carcinomas of the tracheobronchial tree and only those within the range of the flexible fiberbronchoscope.
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References
1.
AulerHBanzerG. Untersuchungen über die Rolle der Porphyrine bei geschwulstkranken Menschen und Tieren. Z Krebsforsch1942; 53: 65–8.
2.
FiggeFHJWeilandGSManganielloLOJ. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins. Proc Soc Exp Biol Med1948; 68: 640–1.
3.
LipsonRLBaldesEJOlsenAM. The use of a derivative of hematoporphyrin in tumor detection. J Natl Cancer Inst1961; 26: 1–11.
4.
LipsonRLBaldesEJ. The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol1960; 82: 508–16.
5.
ClezyPSHaiTTHendersonRWvan ThucL. The chemistry of pyrrolic compounds. XLV. Haematoporphyrin derivative: Haematoporphyrin diacetate as the main product of the reaction of haematoporphyrin with a mixture of acetic and sulfuric acids. Aust J Chem1980; 33: 585–97.
6.
LipsonRLBaldesEJGrayMJ. Hematoporphyrin derivative for detection and management of cancer. Cancer1967; 20: 2255–7.
7.
GregorieHBJrHorgerEOWardJLHematoporphyrin-derivative fluorescence in malignant neoplasms. Ann Surg1968; 167: 820–8.
8.
LeonardJRBeckWL. Hematoporphyrin fluorescence: An aid in diagnosis of malignant neoplasms. Laryngoscope1971; 81: 365–72.
9.
KyriazisGABalinHLipsonRL. Hematoporphyrin-derivative-fluorescence test colposcopy and colpophotography in the diagnosis of atypical metaplasia, dysplasia, and carcinoma in situ of the cervix uteri. Am J Obstet Gynecol1973; 117: 375–80.
10.
CarpenterRJIIINeelHBIIIRyanRJSandersonDR. Tumor fluorescence with hematoporphyrin derivative. Ann Otol Rhinol Laryngol1977; 86: 661–6.
11.
KinseyJHCorteseDASandersonDR. Detection of hematoporphyrin fluorescence during fiberoptic bronchoscopy to localize early bronchogenic carcinoma. Mayo Clin Proc1978; 53: 594–9.
12.
CorteseDAKinseyJHWoolnerLBPayneWSSandersonDRFontanaRS. Clinical application of a new endoscopic technique for detection of in situ bronchial carcinoma. Mayo Clin Proc1979; 54: 635–41.
13.
KinseyJHCorteseDA. Endoscopic system for simultaneous visual examination and electronic detection of fluorescence. Rev Sci Instrum1980; 51: 1403–6.
14.
CorteseDAKinseyJH. Hematoporphyrin-derivative fluorescence for lung cancer localization. Semin Respir Med1981; 3: 37–41.
15.
DiamondIGranelliSGMcDonaghAFNielsenSWilsonCBJaenickeR. Photodynamic therapy of malignant tumours. Lancet1972; 2: 1175–7.
16.
GranelliSGDiamondIMcDonaghAFWilsonCBNielsenSL. Photochemotherapy of glioma cells by visible light and hematoporphyrin. Cancer Res1975; 35: 2567–70.
17.
KellyJFSnellME. Hematoporphyrin derivative: A possible aid in the diagnosis and therapy of carcinoma of the bladder. J Urol1976; 115: 150–1.
18.
DoughertyTJGrindeyGBFielRWeishauptKRBoyleDG. Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst1975; 55: 115–21.
19.
DoughertyTJGomerCJWeishauptKR. Energetics and efficiency of photoinactivation of murine tumor cells containing hematoporphyrin. Cancer Res1976; 36: 2330–3.
20.
DoughertyTJKaufmanJEGoldfarbAWeishauptKRBoyleDMittlemanA. Photoradiation therapy for the treatment of malignant tumors. Cancer Res1978; 38: 2628–35.
21.
DoughertyTJLawrenceGKaufmanJHBoyleDWeishauptKRGoldfarbA. Photoradiation in the treatment of recurrent breast carcinoma. J Natl Cancer Inst1979; 62: 231–7.
22.
WeishauptKRGomerCJDoughertyTJ. Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor. Cancer Res1976; 36: 2326–9.
23.
SignorelliCDAmmiratiMTajanaG. Photochemotherapy of human glioma cells in culture by hematoporphyrin and visible light (preliminary experiment). Acta Neurol (Napoli)1978; 33: 105–12.
24.
SeryTW. Photodynamic killing of retinoblastoma cells with hematoporphyrin and light. Cancer Res1979; 39: 96–100.
25.
ChristensenTMoanJ. Photodynamic inactivation of synchronized human cells in vitro in the presence of hematoporphyrin. Cancer Res1979; 39: 3735–7.
26.
KinseyJHCorteseDAMosesHLRyanRJBranumEL. Photodynamic effect of hematoporphyrin derivative as a function of optical spectrum and incident energy density. Cancer Res1981; 41: 5020–6.
27.
BugelskiPJPorterCWDoughertyTJ. Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse. Cancer Res1981; 41: 4606–12.
28.
ChangCTDoughertyTJ. Photoradiation therapy: Kinetics and thermodynamics of porphyrin uptake and loss in normal and malignant cells in culture, abstracted. Radiat Res1978; 74: 498.
29.
KesselD. Transport and binding of hematoporphyrin derivative and related porphyrins by murine leukemia L1210 cells. Cancer Res1981; 41: 1318–23.
30.
KesselD. Effects of photo-activated porphyrins on cell-surface properties. Biochem Soc Trans1977; 5: 139–40.
31.
KohnKKesselD. On the mode of cytotoxic action of photo-activated porphyrins. Biochem Pharmacol1979; 28: 2465–70.
32.
TorinukiWMiuraTSeijiM. Lysosome destruction and lipoperoxide formation due to active oxygen generated from haematoporphyrin and UV irradiation. Br J Dermatol1980; 102: 17–27.
33.
BodanessRSChanPC. Singlet oxygen as a mediator in the hematoporphyrin-catalyzed photooxidation of NADPH to NADP+ in deuterium oxide. J Biol Chem1977; 252: 8554–60.
34.
MoanJPettersenEOChristensenT. The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin. Br J Cancer1979; 39: 398–407.
35.
BuettnerGROberleyLW. The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spin-trapping. FEBS Lett1980; 121: 161–4.
36.
HariharanPVCourtneyJEleczkoS. Production of hydroxyl radicals in cell systems exposed to haematoporphyrin and red light. Int J Radiat Biol1980; 37: 691–4.
37.
GomerCJ. DNA damage and repair in CHO cells following hematoporphyrin photoradiation. Cancer Lett1980; 11: 161–7.
