Our previous investigation using normal guinea pigs disclosed that, like respiratory mucosa, the middle ear lining has ciliary activity, and that this ciliary activity becomes more active as the location becomes more distal to the eustachian tube. In this experimental study, the effects of Staphylococcus aureus on the middle ear lining was examined from functional and morphological viewpoints. In conclusion, the ciliary activity at the entrance to the eustachian tube and that more distal to the tube present a similar pattern of reaction to S aureus in an in vitro system. On the other hand, the ciliary activity of the middle ear lining displays a varying pattern of reaction according to the locations within the tympanic cavity.
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