Secretory IGA and Bacterial Adherence to Nasal Mucosal Cells

Abstract

The ability of Streptococcus pyogenes to adhere to nasal mucosal cells was investigated by an in vitro assay system in order to clarify the actual role of secretory IgA in mucosal immunity in the nose. The number of bacteria adhering to isolated mucosal cells was significantly larger in patients with chronic sinusitis than in normal control subjects. The ability of bacteria to adhere, however, was significantly lower in the group of subjects having specific secretory IgA antibody activity to the M protein than in those having no secretory IgA activity. Findings demonstrated that mucosal immunity preventing or blocking the adherence of bacteria is impaired in patients with chronic sinusitis.

Keywords

bacterial adherence bacterial proteins nasal mucosa secretory IgA

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References

Gibbons

van Houte

. Selective bacterial adherence to oral epithelial surfaces and its role as an ecological determinant. Infect Immun 1971; 3: 567–73.

Aly

Shinefield

Strauss

Maibach

. Bacterial adherence to nasal mucosal cells. Infect Immun 1977; 17: 546–9.

Ogra

Bernstein

Yurchak

Coppola

Tomasi

Jr. . Characteristics of secretory immune system on human middle ear: Implications in otitis media. J Immunol 1974; 112: 488–95.

Williams

Gibbons

. Inhibition of bacterial adherence by secretory immunoglobulin A: A mechanism of antigen disposal. Science 1972; 77: 697–9.

Kurono

Mogi

. Secretory IgA and serum type IgA in nasal secretion and antibody activity against the M protein. Ann Otol Rhinol Laryngol 1987; 96: 419–24.

Cohen

. Effect of culture medium composition and pH on the production of M protein and proteinase by group A streptococci. J Bacteriol 1969; 99: 743–4.

Ellen

Gibbons

. M protein associated adherence of Streptococcus pyogenes to epithelial surfaces: Prerequisite for virulence. Infect Immun 1972; 5: 826–30.

Alkan

Ofek

Beachey

. Adherence of pharyngeal and skin strains of group A streptococci to human skin and oral epithelial cells. Infect Immun 1977; 18: 555–7.

Beachey

Ofek

. Epithelial cell binding of group A streptococci by lipoteichoic acid on fimbriae denuded of M protein. J Exp Med 1976; 143: 759–71.

10.

Beachey

. Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces. J Infect Dis 1981; 143: 325–45.

11.

Andersson

Fogh

Jørgensen

. Attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells in vitro — Mechanism of binding. Otolaryngol Head Neck Surg 1984; 92: 266–9.