We have extended automated sequential trace enrichment of dialysates and high performance liquid chromatography to include the simultaneous assay of lamotrigine with other anticonvulsant drugs: Phenobarbitone, carbamazepine and phenytoin. The procedure is reliable and precise (between-batch coefficients of variation < 2.8%) with no interference from other commonly prescribed drugs. Patients on lamotrigine presented with serum concentrations up to 67 μmol/L with no adverse effects, suggesting that the therapeutic range may need re-appraisal.
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TurnellDCCooperJD. Total anticonvulsant drugs in plasma or serum (method 2). Gilson ASTED applications guide; 2nd edition. Application 3: AG 3.1–3.5. Villiers-le-Bel, France: Gilson SA, 1990.
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