Neonatal Hyperbilirubinemia: An Unexpected Cause

Hyperbilirubinemia is a common cause for newborn hospital admission. Although the cause of hyperbilirubinemia is usually benign and self-limited, there is always a large differential diagnosis. Atypical presenting signs and symptoms, such as significant anemia or bleeding, should encourage further evaluation for underlying disorders, such as inherited coagulation defects. This article describes the case of a 5-day-old infant who presented to the emergency department with hyperbilirubinemia, anemia, and ecchymoses from birth trauma. His hospital course is described, along with a review on the background, evaluation, management, and complications of hemophilia A.