Growth of Healthy Term Infants Fed Ready-to-Feed and Powdered Forms of an Extensively Hydrolyzed Casein-Based Infant Formula

Abstract

Extensively hydrolyzed formulas present a complex matrix subject to adverse conditions during manufacture that could influence growth and tolerance of infants fed these formulas. A masked, randomized, parallel growth study was conducted in infants fed a ready-to-feed (RTF) or powdered (PWD) form of an extensively hydrolyzed casein-based formula. Infants were enrolled between 0 and 9 days and studied to 112 days of age. Growth, formula intake, and stool patterns were assessed. There were no significant differences between groups in weight, length, head circumference, or their respective gains. Tolerance was similar between groups except that the RTF group had greater formula intakes and passed more stools/day compared to the PWD group. This study demonstrates that the PWD formulation of this RTF formula supports similar growth and tolerance in infants during the first 4 months of life.

Keywords

hydrolysate formula hypoallergenic formula infant feeding infant growth weight Maillard browning

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References

American Academy of Pediatrics. Clinical testing of infant formulas with respect to nutritional suitability for term infants. http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/InfantFormula/ucm170649.htm. Published June 1988. Accessed November 6, 2013.

Adrian

. Nutritional and physiological consequences of the Maillard reaction. World Rev Nutr Diet. 1974;19:71-122.

Tuohy

Hinton

DJS

Davies

Crabbe

Gibson

Ames

. Metabolism of Maillard reaction products by the human gut microbiota—implications for health. Mol Nutr Food Res. 2006;50:847-857.

American Academy of Pediatrics, Committee on Nutrition. Commentary on breast-feeding and infant formulas, including proposed standards for formulas. Pediatrics. 1976;57:278-285.

Infant Formula Act of 1980. Public Law No. 96-359, 94 Stat. 1190 [codified at 21 U.S.C. §350(a), 301, 321 (aa), 331, 374 (a)]. September 26, 1980.

Infant Formula. 21 Code of Federal Regulations (as amended) [412] Sect. 350a, Infant Formulas, October 27, 1986.

World Health Organization Multicentre Growth Reference Study Group. WHO Child Growth Standards: Length/Height-for-Age, Weight-for-Age, Weight-for-Length, Weight-for-Height and Body Mass Index-for-Age: Methods and Development. Geneva, Switzerland: World Health Organization; 2006.

Borschel

Ziegler

Wedig

Oliver

. Growth of healthy term infants fed an extensively hydrolyzed casein-based or free amino acid based infant formula: a randomized, double-blind, controlled trial. Clin Pediatr. 2013;52:910-917.

Scalabrin

Johnston

Hoffman

P’Pool

Harris

Mitmesser

. Growth and tolerance of healthy term infants receiving hydrolyzed infant formulas supplemented with Lactobacillus rhamnosus GG: randomized, double-blind, controlled trial. Clin Pediatr. 2009;48:734-744.

10.

Mennella

Ventura

Beauchamp

. Differential growth patterns among healthy infants fed protein hydrolysate or cow-milk formulas. Pediatrics. 2011;127:110-118.

11.

Burks

Jones

Berseth

Harris

Sampson

Scalabrin

. Hypoallergenicity and effects on growth and tolerance of a new amino acid-based formula with docosahexaenoic acid and arachidonic acid. J Pediatr. 2008;153:266-271.

12.

Ogden

Kuczmarski

Flegal

. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002;109:45-60.

13.

Grummer-Strawn

Reinold

Krebs

; Centers for Disease Control and Prevention. Use of World Health Organization and CDC growth charts for children aged 0-59 months in the United States. MMWR Recomm Rep. 2010;59(RR-9):1-15.

14.

Oates

. Infant-feeding practices. Br Med J. 1973;2:762-764.

15.

Taitz

Byers

. High calorie/osmolar feeding and hypertonic dehydration. Arch Dis Child. 1972;47:257-260.