Objectives. To identify risk factors associated with the prognosis of pertussis-like coughing. Methods. A retrospective study on children hospitalized with pertussis-like coughing from 2018 to 2019. We collected all the case data from medical records including age, gender, vaccination, clinical symptoms, complication, pathogens, white blood cell (WBC) count, lymphocyte ratio, application of macrolide antibiotics, usage of sulfamethoxazole, and usage of inhaled glucocorticoids. Logistic regression was used in this study. Results. A total of 213 hospitalized children with pertussis-like coughing were included in this study. About 70 children were cured within 2 weeks. One120 children were cured from 2 weeks to 3 months, including cases of initial attack and relapse. Symptoms lasting longer than 3 months accounts for 10.8%. Bordetella pertussis, WBC count >20 × 109/L and lymphocyte ratio >60% were associated with poor prognosis (P < .05). Conclusions. Bordetella pertussis, WBC count, and lymphocyte ratio are independent risk factors for poor prognosis.
WilliamsBGGouwsEBoschi-PintoCBryceJDyeC.Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis. 2002;2:25-32.
2.
MulhollandK.Global burden of acute respiratory infections in children: implications for interventions. Pediatr Pulmonol. 2003;36:469-474.
3.
Fernandes-MatanoLMonroy-MuñozIEAngeles-MartínezJ, et al. Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico. PLoS One. 2017;12:e0176298.
4.
Del Valle-MendozaJOrellana-PeraltaFMarcelo-RodríguezA, et al. High prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with acute respiratory infections from Lima, Peru. PLoS One. 2017;12:e0170787.
5.
Pavic-EspinozaIBendezú-MedinaSHerrera-AlzamoraA, et al. High prevalence of Bordetella pertussis in children under 5 years old hospitalized with acute respiratory infections in Lima, Peru. BMC Infect Dis. 2015;15:554-561.
6.
Saiki-MacedoSValverde-EzetaJCornejo-TapiaA, et al. Identification of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized. BMC Infect Dis. 2019;19:75-83.
7.
MooreAHarndenAGrantCCPatelSIrwinRS; CHEST Expert Cough Panel. Clinically diagnosing pertussis-associated cough in adults and children: CHEST guideline and expert panel report. Chest. 2019;155:147-154.
8.
MattooSCherryJD.Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and otherBordetella subspecies. Clin Microbiol Rev. 2005;18:326-382.
9.
WangKBettiolSThompsonMJ, et al. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev. 2014;(9):CD003257.
10.
de CellèsMDMagpantayFMKingAARohaniP.The pertussis enigma: reconciling epidemiology, immunology and evolution. Proc Biol Sci. 2016;283:20152309.
11.
BlackRECousensSJohnsonHL, et al; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010;375:1969-1987.
12.
CastilloMEBadaCDel AguilaO, et al. Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals. Int J Infect Dis. 2015;41:36-41.
13.
FerrerACalicóIManresaJMAndreuAMoragaFValleI.Microorganisms isolated in cases of pertussis-like syndrome [in Spanish]. Enferm Infecc Microbiol Clin. 2000;18:433-438.
14.
DubeFSKabaMRobbertsFJ, et al. Respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in Cape Town, South Africa. BMC Infect Dis. 2016;16:597-609.
15.
MahmoudiSBanarMPourakbariB, et al. Identification of etiologic agents of the pertussis-like syndrome in children by real-time PCR method. Prague Med Rep. 2018;119:61-69.
16.
CherryJD.Pertussis in young infants throughout the world. Clin Infect Dis. 2016;63(suppl 4):S119-S122.
17.
HeiningerUKlichKStehrKCherryJD.Clinical findings in Bordetella pertussis infections: results of a prospective multicenter surveillance study. Pediatrics. 1997;100:E10.
18.
StehrKCherryJDHeiningerU, et al. A comparative efficacy trial in Germany in infants who received either the Lederle/Takeda acellular pertussis component DTP (DTaP) vaccine, the Lederle whole-cell component DTP vaccine, or DT vaccine. Pediatrics. 1998;101(1pt 1):1-11.
19.
WinterKZipprichJHarrimanK, et al. Risk factors associated with infant deaths from pertussis: a case-control study. Clin Infect Dis. 2015;61:1099-1106.
20.
JordanIFelipeABalaguerM, et al. Morbidity and mortality risk factors of pertussis in pediatrics. J Infect. 2017;74:97-100.
21.
StrangertK.Clinical course and prognosis of whooping-cough in Swedish children during the first six months of life. A study of hospitalized patients 1958-67. Scand J Infect Dis. 1970;2:45-48.
22.
NielsenCMWhiteMJBottomleyC, et al. Impaired NK cell responses to pertussis and H1N1 influenza vaccine antigens in human cytomegalovirus-infected individuals. J Immunol. 2015;194:4657-4667.
23.
RobinsonDAMandalBKIronsideAGDunbarEM.Whooping cough—a study of severity in hospital cases. Arch Dis Child. 1981;56:687-691.
24.
LittlerDRAngSYMorielDG, et al. Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins. J Biol Chem. 2017;292:15143-15158.
25.
DeVincenzoJPGuytonCReaH, et al. Molecular detection and quantification of pertussis and correlation with clinical outcomes in children. Diagn Microbiol Infect Dis. 2013;76:10-15.
26.
GaneshalinghamAMcSharryBAndersonBGrantCBecaJ.Identifying children at risk of malignant Bordetella pertussis infection. Pediatr Crit Care Med. 2017;18:e42-e47.
27.
PierceCKleinN.Is leukocytosis a predictor of mortality in severe pertussis infection?Intensive Care Med. 2000;26:1512-1514.
28.
BortolussiRMillerBLedwithMHalperinS.Clinical course of pertussis in immunized children. Pediatr Infect Dis J. 1995;14:870-874.
