Currently, the use of 1 % and 2 % aqueous solutions of gentian violet (GV) is an acceptable treatment of thrush in infants. GV is generally considered efficacious; in fact, one study found GV superior to nystatin in treating thrush in infants. 1 Oral nystatin is usually prescribed as the first-line drug for this infection, while GV is commonly reserved for nystatin failures. Although GV is widely regarded as an essentially harmless medication, we present a case of GV toxicity and review the literature on this subject.
Get full access to this article
View all access options for this article.
References
1.
Kozinn PJTherapy of oral thrush: a comparative evaluation of gentian violet , Mycostatin, and amphotericin B. Monogr Ther.1957;2:16-24.
2.
Slotkowski ELFormation of mucous membrane lesions secondary to prolonged use of one percent aqueous gentian violet. J Pediatr.1957;57:652-654.
3.
John RWNecrosis of oral mucosa after local application of crystal violet . BMJ1968;1:157-158.
4.
Horsfield P. , Logan FA, Newey JAOral irritation with gentian violet. BMJ1976 ;2:528. Letter.
5.
Behrman EB, Vaughn VC, eds. Nelson Textbook of Pediatrics. 13th ed. Philadelphia, PA: WB Saunders Co; 1987.
6.
Avery ME, Tausch HW, eds. Schaffer's Diseases of the Newborn. 5th ed. Philadelphia, PA: WB Saunders Co; 1984.
7.
Fanaroff AF, Martin RJ, eds. Neonatal-Perinatat Medicine, Diseases of the Fetus and Infant . 4th ed. St. Louis, MO: CV Mosby Co; 1987.
8.
Eichenwald HF, Stroeder S , eds. Current Therapy in Pediatrics. 1 st ed. Philadelphia, PA: BC Decker Inc; 1989.
Avery ME, First LR, eds. Pediatric Medicine. 1st ed. Baltimore, MD: Williams & Wilkins; 1989.
11.
Schwartz MW, Charney EB, Curry TA, Ludwig S, eds. Pediatric Primary Care. A Problem Oriented Approach. 1 st ed. Chicago, IL: Year Book Medical Publishers ; 1987.