A Case of Ivermectin-Induced Warfarin Toxicity: First Published Report

Abstract

Here, we present the case of a patient who developed a large hematoma under his tongue while taking concomitant warfarin and ivermectin. Ivermectin has been shown to interfere with vitamin K–dependent clotting factors II, V, VII, and X. However, all the data to date have been from in vivo data with little to no reports on its effects on humans. To our knowledge, this is the first case report to present such a case.

Keywords

adverse drug reactions anticoagulants anti-infectives drug interactions Warfarin

Get full access to this article

View all access options for this article.

References

Bernigaud

Fang

Fischer

et al . Preclinical study of single-dose moxidectin, a new oral treatment for scabies: efficacy, safety, and pharmacokinetics compared to two-dose ivermectin in a porcine model. PLoS Negl Trop Dis. 2016;10(10):e0005030.

González Canga

Sahagún Prieto

Diez Liébana

et al . The pharmacokinetics and interactions of ivermectin in humans—a mini-review. AAPS J. 2008;10(1):42-46. doi:10.1208/s12248-007-9000-9.

Whitworth

Hay

McNicholas

Morgan

Maude

Taylor

DW.

Coagulation abnormalities and ivermectin. Ann Trop Med Parasitol. 1992;86(3):301-305.

Hay

Arnott

MA.

Ivermectin and coagulation: an in vitro study. Ann Trop Med Parasitol. 1990;84(5):503-506.

Richards

JR Mcneeley

Bryan

et al . Ivermectin and prothrombin time. The Lancet. 1989;333(8647):1139-1140.