Epithelial or mesenchymal isolates cultivated on the chicken chorioallantoic membrane singly do not possess the potential for tooth morphogenesis. However, when randomly recombined in vitro, their histogenic interaction relates to tooth formation. After 16 days of continuous culture, surviving recombinants formed an advanced tooth germ. Such structures did not, however, demonstrate uniformity in odontogenesis or in developmental cusp patterns.
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