Spatial Distribution of Cells in Mitotic and DNA-Synthetic Phases of the Cell Cycle in Hamster Cheek Pouch Epithelium

Abstract

The spatial distributions of dividing and DNA-synthesizing cells in sections of cheek pouch epithelium of Chinese hamsters were subjected to four statistical tests for randomness. The results were consistent with, and provided statistical support for, the observation that localized regions of high mitotic and labeling indices occur in this tissue, separated by broad zones of low activity.

Get full access to this article

View all access options for this article.

References

Thuringer, J.A. : Studies on Cell Division in the Human Epidermis, Anat Rec 40: 1-13, 1928.

Henry, J.L. ; Meyer, J. ; Weinmann, J.P. ; and Schour, I. : Pattern of Mitotic Activity in Oral Epithelium of Rabbits, Arch Path 54:281-297, 1952.

Scheving, L.E. : Mitotic Activity in the Human Epidermis, Anat Rec 135:7-19, 1959.

Meyer, J. ; Medak, H. ; and Weinmann, J.P. : Mitotic Activity and Rates of Growth in Regions of Oral Epithelium Differing in Width, Growth 24:29-46, 1960.

Frei, J.V. ; Waugh, W.O. ; and Ritchie, A.C. : Mitoses: Distribution in Mouse Ear Epidermis, Science 140:487-488, 1963.

Cameron, I.L. ; Gosslee, D.G. ; and Pilgrim, C. : The Spatial Distribution of Dividing and DNA-Synthesizing Cells in Mouse Epithelium, J Cell Comp Physiol 66:431-435, 1965.

Reiskin, A.B. , and Mendelsohn, M.L. : A Comparison of the Cell Cycle in Induced Carcinomas and Their Normal Counterpart, Cancer Res 24:1131-1136, 1964.

Wine, R.L. : Statistics for Scientists and Engineers, Englewood Cliffs, NJ: Prentice-Hall, Inc., 1964, pp 611-616.

Feinendegen, L.E. : Tritium-Labeled Molecules in Biology and Medicine, New York: Academic Press, 1967.

10.

Greulich, R.C. ; Cameron, I.L. ; and Thrasher , J.D. : Stimulation of Mitosis in Adult Mice by Administration of Thymidine, Proc Nat Acad Sci USA 47:743-748, 1961.

11.

Gibbs, S.J. , and Casarett, G.W. : Influences of a Circadian Rhythm and Mitotic Delay from Tritiated Thymidine on Cytokinetic Studies in Hamster Cheek Pouch Epithelium, Radiat Res 40:588-600, 1969.

12.

Leblond, C.P. ; Greulich, R.C. ; and Pereira, J.P.M. : Relationship of Cell Formation and Cell Migration in the Renewal of Stratified Squamous Epithelia, in Mon-Tagna, W., and Billingham, R.E. (eds): Wound Healing, New York: Macmillan Co., 1964, pp 39-67.

13.

Lajtha, L.G. ; Gilbert, C.W. ; Porteous, D.D. ; and Alexanian , R. : Kinetics of a Bone Marrow Stem Cell Population, Ann NY Acad Sci 113:742-752, 1964.