Spiramycin Excretion in Animals: II. Repeated Oral Doses in Rats

Abstract

After 7 to 14 spiramycin doses, plasma and selected tissues were assayed for residual antibiotic. Plasma contained detectable spiramycin only in samples taken 24 hours after the last 400 mg/kg dose. After 100 to 400 mg/kg levels, spiramycin remained in mandibular gingiva and bone at least seven days. Parotid and submaxillary glands contained antibiotic 24 hours after 25 to 400 mg/kg doses and 14 to 21 days after 400 mg/kg doses.

Get full access to this article

View all access options for this article.

References

Harvey, R.F. : Clinical Impressions of a New Antibiotic in Periodontics: Spiramycin, J Can Dent Assoc 27:576-585, 1961.

Menzel, H.J. : Clinical Experiences with Spiramycin in the Prophylaxis and Treatment of Inflammatory Conditions in the Oral Cavity, ZWR 69:191-193, 1968.

Lambrou, D. : The Values of Some Antibiotics in the Treatment of Periodontal Diseases , Odontiatiki 1:139-142, 1968.

Pellerat, J. : On the Salivary Elimination of Several Antibiotics , Presse Med 71 :2135-2136, 1963 .

Yankell, S.L. ; Leung, F.C. ; Gardner , J.M. ; and Paor, W.S. : Spiramycin Excretion in Animals: I. A Single Oral Dose in Rats, J Dent Res 50:1359, 1971.

Yankell, S.L. ; Leung, F.C. ; Moreno , O.M. ; and Moriarity , A.J. : Spiramycin Excretion in Unanesthetized Dogs, Pharmacol Lab 13:295, 1971.

Kavanagh, F. : Analytical Microbiology, New York: Academic Press, 1963.

Tsvetanova, M. , and Klein-Genova , S. : Deposit and Length of Retention of Rovamycin (Spiramycin) in the Bones and its Level in Rat's Blood Serum After Oral Administration, Stomatologia (Sofia) 49: 261-266, 1967.

Tsvetanova, M. , and Klein-Genova , S. : La Spiramycine en Parodontologie. Accumulation et duree de sa Retention dans les Os et sa Teneur dans le Serum Sanguin chez les Rats apres Application per Os, Inform Dent 50:2546-2552, 1968.

10.

Tsvetanova, M. , and Klein-Genova , S. : Comparative Studies on the Deposition and Length of Retention of Spiramycin, Tetracycline and Erythromycin in the Serum, Jaw and Long Bones of White Rats, Stomatologia (Sofia) 50:364-369, 1968.