Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa: I. Effect of Medroxyprogesterone Acetate (MPA) on the Soluble Supernatant (Cytosol) Activating Microsomal Δ4-3-Ketosteroid-5α-Reductase and 17β -Hydroxysteroid Oxidoreductase Enzyme Systems
Restricted accessResearch articleFirst published online November, 1978
Cellular Regulation of the Metabolism of Androgens in Rat Oral Mucosa: I. Effect of Medroxyprogesterone Acetate (MPA) on the Soluble Supernatant (Cytosol) Activating Microsomal Δ4-3-Ketosteroid-5α-Reductase and 17β -Hydroxysteroid Oxidoreductase Enzyme Systems
Soluble supernatant (cytosol) of rat oral mucosa was found to contain a factor accelerating the activity of microsomal Δ4-3-ketosteroid-5α-reductase and 17β-hydroxysteroid oxidoreductase enzymes metabolizing testosterone. Systemic administration of medroxyprogesterone acetate further increased this cytosolic activity.
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