Abstract
Text-to-speech and related read-aloud tools are being widely implemented in an attempt to assist students’ reading comprehension skills. Read-aloud software, including text-to-speech, is used to translate written text into spoken text, enabling one to listen to written text while reading along. It is not clear how effective text-to-speech is at improving reading comprehension. This study addresses this gap in the research by conducting a meta-analysis on the effects of text-to-speech technology and related read-aloud tools on reading comprehension for students with reading difficulties. Random effects models yielded an average weighted effect size of (
Reading comprehension, which is defined as the ability to construct meaning from interacting with a text, is critical for students to succeed in today’s educational settings (Snow, 2002). For students with reading disabilities, reading comprehension is often difficult (Kim, Linan Thompson, & Misquitta, 2012). Most current theories argue that one of the primary causes of reading disabilities is a struggle to decode written text. This has a direct negative effect on reading comprehension by decreasing word reading accuracy and speed. Inefficient decoding may also tax cognitive resources, leaving fewer resources available for comprehension (Smythe, 2005).
Presenting reading material orally in addition to presenting it in a traditional paper format removes the need to decode reading material and therefore has the potential to help students with reading disabilities better comprehend written texts. There are several technologies for presenting oral materials (e.g., text-to-speech, reading pens, audiobooks). Previously text was available orally through books-on-tape and human readers. More recently, text-to-speech technology has been used widely in educational settings from elementary school through college. Unfortunately, its implementation has outpaced the lagging research base on the effects of using text-to-speech to support comprehension. The research literature is characterized by contradictory results, with some studies reporting improved reading and others not (Dalton & Strangman, 2006; Stetter & Hughes, 2010; Strangman & Hall, 2003). Due to these mixed findings, we wanted to conduct a current review of the literature. The goal of this meta-analysis is to synthesize the research literature on the effects of text-to-speech and related tools for oral presentation of material on reading comprehension for students with reading disabilities.
Individuals with reading disabilities have unexpected significant deficits in reading and its component skills (e.g., decoding, fluency) despite potential educational opportunities. This reading deficit is believed to have a neurobiological basis and is also characterized by a failure to respond to appropriate instruction and intervention (Fletcher, 2009; Lyon, Shaywitz, & Shaywitz, 2003; Wagner, Schatschneider, & Phythian-Sence, 2009).
Common problems for individuals with reading disabilities include inaccurate and slow word reading and reading of connected text, making comprehension challenging (LaBerge & Samuels, 1974; Perfetti, 1985). Mastery of lower level decoding skills is essential for being able to use higher level language skills to understand text (Cain, Oakhill, & Bryant, 2004).
Intervention Versus Compensation
Intervention studies seek to improve students’ reading skills independent of the technology. In contrast, compensation studies seek to provide students with an assistive tool to help them with their reading. Intervention-oriented studies use text-to-speech tools to improve unassisted reading skills, whereas compensation-oriented studies address the use of text-to-speech tools to compensate for word-level skill deficits and gain access to written material. It is often unclear how to tell when intervention has failed and when students should begin to use compensation (Edyburn, 2007). Although educators would like to improve students’ basics skills as much as possible, not all students are able to reach proficient reading skills. The goal of compensation is designed to help students access texts. If comprehension problems of students with reading disabilities stem at least in part from decoding deficits, then reducing or eliminating the decoding requirement should improve reading comprehension. Oral presentation of material including text-to-speech helps eliminate the decoding requirement by reading the words aloud to the student, thus enabling comprehension (Olson, 2000). Text-to-speech and read-aloud text presentation tools are used in both interventions and compensation settings. We included both intervention and compensation studies in this review but also added a moderator variable to represent this distinction to determine whether comparable effects emerged from both kinds of studies.
Additionally, some students with reading disabilities are relatively accurate at decoding but are slow readers and may be unable to keep up with reading assignments. This becomes increasingly true as students move into more advanced course work (i.e., college reading) (Jones, Schwilk, & Bateman, 2012). Text-to-speech may enable students to read material that is beyond their basic word-reading level while matching their interests and listening comprehension abilities.
Use of Text-to-Speech and Other Read-Aloud Tools in Education
Text-to-speech technology development began in the 1980s and has been rapidly increasing. With technological advances, practitioners and education researchers have begun to use text-to-speech and related tools to help students with reading disabilities. In text-to-speech, the text is paired either with a synthesized computer or human recording of that same text (Biancarosa & Griffiths, 2012). As computer technology has improved over the past 20 years, the prevalence and quality of electronic versions of books and computer software with text-to-speech capabilities have also increased. Text-to-speech software development is occurring worldwide in diverse locations, including the United States, Egypt, and Europe (Smythe, 2005). Examples of such programs are DecTalk, ClassMate Reader, Texthelp Read & Write Gold, and Kurzweil 3000 (Berkeley & Lindstrom, 2011). The number of free and easily accessible text-to-speech software programs is increasing (Berkeley & Lindstrom, 2011). There are many statewide implementations, including examples from Kentucky and Missouri (Goddard, Kaplan, Kuehnle, & Beglau, 2007; Hasselbring & Bausch, 2005). These programs commonly contain voice options, custom pronunciation, creation of synthetic audio files, and other assistive tools such as text highlighting (Peters & Bell, 2007). Text-to-speech technology features can greatly affect the users’ experience and thus may affect its effectiveness. Some of these features include reading rate, voice type, document tagging (which affects reading order), and dynamic highlighting. Reading rate can greatly affect the users’ experience (Lionetti & Cole, 2004). When users choose text-to-speech software, a consistent comment is the desire to have software that follows natural speech and prosody. These subtle differences of reading rate, voice, document formatting, and dynamic highlighting between text-to-speech systems may affect overall user experience and thus may contribute to the mixed findings in the literature.
In addition to different features of text-to-speech tools, individual differences in users may affect the users’ text-to-speech experience. Individuals with clinical diagnoses of reading disabilities are heterogeneous. Some may be more skilled at decoding than others and thus may benefit differently from text-to-speech/read-aloud tools. Also, many have comorbid diagnoses, such as attention deficit/hyperactivity disorder, which may affect their reading performance. In addition, personality and social factors interacting with their disabilities may either facilitate or decrease text-to-speech use (Parette & Scherer, 2004; Parr, 2012). Finally, having supportive and knowledgeable technical help with the software, particularly at school, increases students’ ability to use and integrate this technology effectively into their daily lives (King Sears, Swanson, & Mainzer, 2011; Newton & Dell, 2009). These differences may lead to different compensation patterns, which may affect interactions with read-aloud/text-to-speech accommodations.
As previously mentioned, the results of several reviews of the literature have not yielded consistent findings about whether text-to-speech improves comprehension (e.g., Hall, Hughes, & Filbert, 2000; MacArthur, Ferretti, Okolo, & Cavalier, 2001; Moran, Ferdig, Pearson, Wardrop, & Blomeyer, 2008; Stetter & Hughes, 2010; Strangman & Dalton, 2005). More recently, two meta-analyses investigated the compensatory effects of read-aloud accommodations on assessments (Buzick & Stone, 2014b; Li, 2014b). These studies investigated read-aloud accommodations for students with and without disabilities (focused more broadly than just reading disabilities) on English and math assessments. Comprehensive comparative comments on the two studies can be found in (Buzick & Stone, 2014a; Li, 2014a); however, we will provide a brief description of the two studies to illustrate how the current study extends the previous findings.
Li (2014b) was focused on two general questions of the effects of read-aloud accommodations for students with and without disabilities on reading assessments and which factors would influence those effects of read-aloud accommodations. Those factors were explored through moderators (e.g., disability status and content area), and effect sizes were compared utilizing hierarchical linear modeling. Therefore, they focused on using these moderators to explain the variability between student groups and topics. Having broad inclusionary criteria such as including both quasi-experimental and experimental studies as well as published and unpublished studies created a large enough pool, which enabled moderator analysis. The results revealed smaller effect sizes for read-aloud accommodations for math assessments compared to reading assessments regardless of student disability status. Additionally, students with disabilities did not benefit differentially on math assessments compared to students without disabilities.
Buzick and Stone (2014b) carried out a meta-analysis that addressed the effects of read-aloud accommodations for students with and without disabilities on standardized assessments, whether read-aloud accommodations improve test scores more for students with disabilities compared to students without disabilities, and what factors contribute to differences between the effects of students with and without disabilities for read-aloud accommodations. Their inclusionary criteria were stricter than those used by Li (2014a), resulting in a smaller number of studies included in the meta-analysis. The results supported those of Li (2014a) in that smaller effects were found for math assessments compared to reading assessments regardless of student disability status. Additionally, students with disabilities did not benefit differentially on math assessments compared to students without disabilities.
The two previous meta-analyses included students regardless of disability type, and their focus was on large-scale standardized tests that were not specific to reading comprehension. The focus of the current meta-analysis was the effects of text-to-speech and related tools on reading comprehension for individuals with reading disabilities. Additionally, we considered small-n studies, sometimes known as single-case studies, which are commonly used in the field of special education. Recently new methods have become available to calculate a standardized effect for single-case studies, which can be combined with between-subjects studies (Shadish & Lecy, 2015). These methods are now recommended for use as described in a recent paper commissioned by the National Center for Education Research and the National Center for Special Education Research (Shadish, Hedges, Horner, & Odom, 2015).
We hope to extend the findings from the previous meta-analyses by (a) calculating effect sizes for just students with reading disabilities using read-aloud tools on reading comprehension assessments and (b) including additional moderator variables (e.g., delivery method, intervention vs. compensation, amount of reading material presented using the read aloud). Three questions were addressed in this meta-analysis:
What is the average weighted effect size of the use of text-to-speech and related tools on reading comprehension for students with reading disabilities?
Are there identifiable moderators of the effects of text-to-speech and related tools on reading comprehension?
What is the overall quantity and quality of the current research base on students with reading disabilities using text-to-speech software to assist with reading comprehension, and are there important gaps in the literature?
Method
Inclusionary Criteria
Inclusionary criteria were developed to reflect the diversity of technology and settings in which participants used oral presentations of text. The below were used in this meta-analysis:
Reading comprehension must be measured at the sentence, paragraph, or passage level. Both researcher-designed and norm-referenced assessments were included.
Only studies in which the effect sizes could be calculated for students with dyslexia, reading disabilities, or learning disabilities (subtype reading) were included. Due to the diversity and lack of consensus in the definition of reading disabilities (Quinn & Wagner, 2013), an inclusive definition was used. Students could have more than one disability but had to have a reading disability as well.
All studies must include a condition with oral presentation of the reading material. Presentation type may be any of the following: human recorded audio, human readers, or a variety of technology, including synthesized text-to-speech, reading pens, or other eBooks with text-to-speech or oral capabilities.
Studies must be reported in English.
Additionally, in order to gain a complete quantitative synthesis with minimal publication bias, this meta-analysis included all types of literature: peer-reviewed studies, unpublished reports, theses, dissertations, conference proceedings, and poster presentations. Because of variability in the grade at which students with reading disabilities are identified, we restricted our meta-analysis to studies of third grade and above, the grade by which most students with reading disabilities have been identified. The search was not limited by quantitative study design (experimental, quasi-experimental, or observational), utilization of preexisting data, or year; however, qualitative studies were excluded.
Search Procedures
Studies were gathered through a comprehensive and systematic search that utilized multiple methods: searching databases, checking previously published studies’ bibliographies, and contacting experts in the text-to-speech research field. The following databases were used: Education Resources Information Center, Dissertation and Theses, PsycINFO, Linguistic and Language Behavior Abstracts, and ComDisDom provided by Proquest; Education Full Text and Academic Search Complete provided by EBSCO; Web of Science provided by Thomson Reuters; Expanded Academic ASAP provided by GALE; and Google Scholar provided by Google.
Three groups of search terms describing the outcome variable (reading comprehension), the population of interest (students with reading disabilities/dyslexia), and the oral modality of reading material (read aloud/text-to-speech) were used in various combinations, depending on each database’s thesaurus. The topic of “reading comprehension” was searched with the following terms: “reading comprehension,” or “comprehension tests,” or “reading comprehension tests.” Next, various terms referring to dyslexia were connected to the reading comprehension topic using the Boolean AND operator including “response to intervention,” or “learning dis*,” “reading disabilities,” “dyslex*,” or “special education students,” or “disabilities.” These search statements were then combined using the Boolean AND operator with various terms referring to the pairing of audio and visual representations of the text simultaneously. These terms reflect the diversity of text delivery including text-to-speech technology, human readers, and other read-aloud accommodations: “text-to speech synthesizer,” or “text to speech,” or “text-to-speech,” or “speech synthes*,” or “synthes* speech” or “speech synthesizers,” or “oral reading,” or “read aloud,” or “book on tape,” or “audio books,” or “assistive technology,” or “examinations,” or “academic accommodations,” or “testing accommodations.” Collectively all of the various search combinations yielded 2,933 records, which were reviewed, and finally duplicates were deleted. Initial screening of the search results involved reading titles and abstracts to assess their fit with this review of text-to-speech technology for individuals with reading disabilities. “Reading disabilities” was broadly defined so as not to exclude potentially useful studies. This review of titles and abstracts excluded 2,874 records, leaving 59 records remaining.
Additionally, “backwards mapping” was utilized by identifying 14 other relevant studies from the references list. Of these studies 3 did not have the appropriate population or disability categories (Crawford & Tindal, 2004; Koretz & Hamilton, 2000; Randall & Engelhard, 2010). The 11 remaining studies were retained for further review. Also, experts in the field were contacted for additional studies. This resulted in finding 6 additional studies, of which 3 were already included (Boyle et al., 2003; Hodapp, Judas, Rachow, Munn, & Dimmitt, 2007; Roberts, Takahashi, Park, & Stodden, 2013). The last 2 studies of the 6 identified were not included because 1 was not about reading comprehension (Orr & Parks, 2007) and we were not able to extract data on the treatment groups for the other study (Swan, Kuhn, Groff, & Roca, 2005).
Collectively, all of the search methods yielded 81 articles, which were reviewed in full text. Studies were excluded from the meta-analysis based on the following six exclusionary criteria: qualitative studies, synthesis studies (literature reviews and meta-analyses), multiple interventions without reading comprehension reported separately from other interventions, missing a silent reading condition, not conducted in the students’ native language, and inaccessible full-text versions of studies. More details are available upon request from the first author about methods, including which specific studies were excluded for which reasons. The remaining 43 records were then reviewed for possible inclusion within the meta-analysis.
Coding Procedure
Before coding began, studies for which the effect sizes could not be calculated were removed (see Note 1). In an attempt to get more information about the studies, we contacted the studies’ authors. Next, the following characteristics of the studies were coded: What was read aloud (divided between partial versus entire passages and whether comprehension questions were read aloud), type of oral modality (categorized into one of the three terms: synthesized text-to-speech, human readers, recorded human voice), reading material difficulty (categorized into at the participants’ grade levels or reading levels), intervention (defined as using oral presentation to improve students’ basic deficits so they can become better readers independent of technology), compensation (defined as utilizing technology as a long-term reading solution, like glasses for fixing vision problems), ability to repeat oral reading material, decoding (defined as students’ decoding skills being needed for any part of the passage or comprehension assessment), participant grade (defined as a student’s grade level represented in the sample [see Note 2]), and type of publication (categorized into either published or unpublished). For between-subjects studies, the following three additional characteristics were coded: randomization (defined as an equal chance of participants’ receiving random treatment or control condition), differential sample attrition, and group equivalence (defined as intervention and control groups’ performing similarly on measured pretest variables). To ensure coding accuracy a second rater coded 20% of the studies. Overall reliabilities were 0.95 for total interrater agreement and 0.94 for overall Kappa. The range of the interrater agreement across the codes was 0.90 to 1.00 (except for decoding at 0.60). Kappa was 1.00 for all codes except decoding (0.28), intervention (0.65), and what was read aloud (0.73), respectively. Coding discrepancies were resolved through discussion except for the decoding moderator, which was coded by a third rater. The third rater was in agreement with the first rater with Kappa = 1.00 and not in agreement with the second rater with Kappa = 0.40. We went with the codes provided by the first and third raters as the second rater appeared to have trouble rating this variable.
Results
Effect Size Calculations
Effect sizes were calculated for the 22 remaining studies (see Note 3). We calculated effect sizes for all studies, except single-case studies, using the equations in Cooper, Hedges, and Valentine (2009). We used the standardized mean difference (Hedges g, which is Cohen’s d with a correction, noted in this paper as
Data Analyses
The analyses were conducted using the metafor package (Viechtbauer, 2010) as implemented in R. The package reports restricted maximum likelihood (Harville, 1977) estimates of the pooled effect size and also reports several measures of heterogeneity including Q (Q represents the amount of total heterogeneity in the study and follows a χ2 distribution with k − 1 degrees of freedom) (J. P. T. Higgins & Thompson, 2002) and remaining unexplained heterogeneity (for the moderator analysis) (see Note 4), which we reported. We also estimated the effects of potential publication bias using the trim and fill method (Duval & Tweedie, 2004) as well as funnel plots (Cooper et al., 2009).
The results show that the use of text-to-speech tools has a significant impact on reading comprehension scores with
Summary of Included Articles.
Note.
Researcher modified.

Forest plot of effect sizes.

Funnel plot showing (A) the heterogeneity of all studies included in the meta-analysis and (B) the residual heterogeneity after controlling for if the study was between subjects or within subject.
Our effect size is consistent with the previous meta-analyses (Buzick & Stone, 2014b; Li, 2014b) although with a somewhat smaller average weighted effect size. A possible contributing factor to our smaller average effect size was that we had three within-subject studies with negative effect sizes in our pool that were not in either of the previous meta-analyses (E. L. Higgins & Raskind, 1997; Hodapp et al., 2007; Thurlow, Moen, Lekwa, & Scullin, 2010). Without these studies the results are more positive and remain significant,
In contrast to previous meta-analyses, our study contained postsecondary and adult subjects, but if we only analyzed studies for K–12 we still obtained similar results,
For the moderator analyses, only a single, significant moderator emerged, namely, whether the study design was a between-subjects or within-subject study. The average weighted effect size for between-subjects studies alone was
Discussion
The impact of text-to-speech and related read-aloud tools for text presentation on reading comprehension for individuals with reading disabilities was explored in this meta-analysis. Three questions were explored and will be discussed in turn.
Average Effect Size of the Use of Text-to-Speech on Measures of Reading Comprehension
Our meta-analysis provides a more focused approach than previously taken as we looked exclusively at students with reading disabilities using read-aloud tools on reading comprehension assessments. This is motivated by a previous meta-analysis finding that indicated that presentation accommodations (segmented reading and read aloud) had a significant positive effect for students with learning disabilities but did not have an effect for students requiring special education services (Vanchu-Orosco, 2012). Both meta-analyses published in 2014 included many types of disabilities without distinguishing among them, whereas in the current study we focus exclusively on students with reading disabilities. Another difference is that the previous meta-analysis (Buzick & Stone, 2014b) focused mostly on state assessments and other large standardized assessments. Many large-scale assessments test general English skills, not solely reading comprehension. Here, we specifically chose to examine reading comprehension tests. Through this narrow focus on students with reading disabilities and reading comprehension assessments, our model hopes to expand the previous studies to provide new information about moderators affecting the effectiveness of read-aloud tools on reading comprehension.
The effects of text-to-speech and related read-aloud tools indicate that oral presentation of text for students with disabilities helps their reading comprehension test scores. Our finding of an average weighted effect size of .35 is consistent with the recent meta-analysis results on read-aloud accommodations for students with disabilities (Buzick & Stone, 2014b; Li, 2014b). Taken together, this meta-analysis is useful as a starting point to begin quantifying the wide range of published and unpublished read-aloud literature.
Amount of Variability Present and Identifiable Moderators in Effect Sizes
There was significant heterogeneity present. The moderator of between-subjects versus within-subject study design was found to be significant. Possible reasons for this may include regression to the mean, attrition, and order effects due to lack of counterbalancing treatments (Li, 2014b). Interestingly, none of the other moderators were significant in the random effects model. Potential carry-over or training effects of reading with assistive technology may contribute to these differences. Nonsignificant moderators included what was read aloud, type of oral modality, reading material difficulty, intervention, compensation, ability to repeat oral reading material, decoding needed, and grade level. We were surprised that grade level did not moderate the effect of the text-to-speech/read-aloud presentation. This is in contrast to the previous meta-analyses, which found grade level a significant moderator (Buzick & Stone, 2014b). However, depending on how the variation in effect sizes between studies is conceptualized, it affects the amount of variance accounted for by the grade-level moderator (see Table 2; see Note 5).
Moderator Analysis.
Note. K = number of studies included; B = change in effect size of one-unit increase in moderator; QM = heterogeneity explained by the moderator; QE = remaining unexplained heterogeneity.
p < .05. **p < .01.
In addition, we were surprised that whether the study used text-to-speech/read-aloud tools in an intervention setting did not emerge as a significant moderator. Using the text-to-speech/read-aloud tools as intervention is theoretically and practically different than using text-to-speech/read-aloud tools in a compensation setting. There were very few studies that were truly interventions despite many studies claiming to be interventions. More research comparing intervention versus compensation approaches needs to be conducted.
The Quantity and Quality of Research on Students Using Text-to-Speech and Related Read-Aloud Tools for Reading Comprehension
Initial search results suggest that this is an active and growing area of research. We found 81 articles for full-text review while applying exclusionary criteria. We found a small number of studies from the 1980s and 1990s. The literature is growing, and the rate of new studies being conducted is increasing with time. Interestingly, the amount of studies using the computerized text-to-speech read-aloud tool is increasing. For example, the studies from the 2010s all used text-to-speech technology. This may reflect the trend of wider access to improved text-to-speech technology.
However, study quality remains a concern, with many studies missing key components such as proper controls and adequate statistical reporting. Additionally, many studies used convenience samples (e.g., Boyle et al., 2003). It is important to have randomized treatment-controlled studies to make causal inferences about the effect of text-to-speech/read-aloud tools in an educational context, thus increasing ecological validity by capturing the diversity of the current classroom. However, there are trade-offs between internal and external validity that are difficult to balance. It is ideal to have large sample sizes, but they should also be as homogeneous as possible, allowing the best possible assessment of the read-aloud/text-to-speech presentation. However, small-sample studies could be useful for identifying students’ disabilities and then allowing intensive study of these individual differences. The downside to them is external validity because you are not able to have a large enough sample size to extend to various types of learning disabilities. However, the studies’ high internal validity is beneficial to this field. Taken together, new studies with clear and complete reporting of both between-subjects and within-subject study designs will be beneficial.
Limitations and Future Directions
There are a few limitations that are worth noting. First, our study included a relatively small sample size (n = 22 studies); however, this is still larger than previous findings. Second, reading comprehension measures and text-to-speech interventions were diverse and were applied at different intensities. Analyzing the importance of intensity of interventions seems particularly interesting, but due to inconsistent reporting, we were unable to develop a meaningful measure of intensity. Third, placebo effects and motivation have yet to be explored or explicitly controlled for. Currently, there is a lack of randomized control trials; these studies will help provide evidence as to whether and how assistive technology affects students’ reading comprehension test scores.
In future studies, measurements of participants’ reading skills such as decoding, working memory, vocabulary, and listening and reading comprehension should be assessed. Text-to-speech technology features including speech speed, text highlighting, and intensity need to be explicitly addressed. With the advent of systemwide user tracking (e.g., length of use, user preferences) of text-to-speech programs, such as Read & Write Gold and Kurzeweil 3000, users’ actions can be recorded. This data can be combined with student characteristics like reading level and disability status as well as their reading test outcomes to see how students should be utilizing the software. These data could then be compared to the students’ reading comprehension measures with text-to-speech/read-aloud tools in compensatory settings such as a statewide reading comprehension test. This enables large quantities of data to be collected, but the quality of the data this monitoring provides is questionable. In summary, future research should investigate the following: features of text-to-speech tools, participant reading characteristics and disabilities, study design considerations, and larger scale usage studies.
Conclusion
Text-to-speech/read-aloud presentation positively affects reading comprehension for individuals with reading disabilities, with average weighted effect sizes of
Footnotes
Authors’ Note
Thank you to the following experts in assistive technology for responding to our request for additional data and/or providing access to unpublished data: Cynthia M. Okolo, Sara M. Flanagan, Emily Bouck, Maria Earman Stetter, Marie Tejero Hughes, Richard E. Ferdig, Tracey Hall, E. A. Draffan, Terry Thompson, Margaret Bausch, Ted S. Hasselbring, Jane Hauser, Melanie Kuhn, Dave Edyburn, and Chuck Hitchcock. Elizabeth L. Tighe is now at Georgia State University, Atlanta, USA.
Declaration of Conflicting Interests
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Support for this project was provided by grant number P50 HD052120 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
