An attempt was made to assay the analgesic potency of haloperidol (.15, .30, 2.5, 5.0 mg/kg) in the rat, using the spatial preference technique. This drug was able to raise the aversive threshold in a dose-dependent manner in doses at or above .15 mg/kg. These same dosages, however, also significantly reduce the number of motor responses made during threshold testing. These results were interpreted to suggest that haloperidol produces its effects on the aversive threshold indirectly by inhibiting the execution of the escape response.
References
1.
HouserV. P.ParéW. P.A method for determining the aversive threshold in the rat using repeated measures: Tests with morphine sulfate. Behav. Res. Meth. & Instru., 1972, 4, 135–137.
2.
HouserV. P.ParéW. P.Analgesic potency of sodium salicylate, indomethacin, and chlordiazepoxide as measured by the spatial preference technique in the rat. Psychopharmacologia, 1973, 32, 121–131.
3.
HouserV. P.Van HartD. A.The effect of chlorpromazine and imipramine upon the aversive threshold of rats. Physiol. Psychol., 1974, 2, 333–336.
4.
MyersJ. L.Fundamentals of experimental design. Boston: Allyn & Bacon, 1966.
5.
ReusJ. F.HouserV. P.PareW. P.An electronic constant current shock generator for low current levels. Physiol. & Behav., 1971, 7, 635–637.
